NeuroElectro Publications

Article: Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Hedrich UB; Liautard C; Kirschenbaum D; Pofahl M; Lavigne J; Liu Y; Theiss S; Slotta J; Escayg A; Dihné M; Beck H; Mantegazza M; Lerche H
J. Neurosci., 2014

Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Hippocampus CA1 basket cell	Hippocampus CA1 Stratum Oriens fast-spiking inhibitory neuron	input resistance (MΩ)	174.9 ± 11.4 (7)	174.9 (MΩ)	Data Table
Hippocampus CA1 basket cell	Hippocampus CA1 Stratum Oriens fast-spiking inhibitory neuron	resting membrane potential (mV)	-74.5 ± 5.1 (7)	-74.5 (mV)	Data Table
Hippocampus CA1 basket cell	Hippocampus CA1 Stratum Oriens fast-spiking inhibitory neuron	rheobase (pA)	50.0 ± 9.5 (7)	50.0 (pA)	Data Table
Hippocampus CA1 basket cell	Hippocampus CA1 Stratum Oriens fast-spiking inhibitory neuron	spike threshold (mV)	-54.4 ± 1.0 (7)	-54.4 (mV)	Data Table
Hippocampus CA1 basket cell	Hippocampus CA1 Stratum Oriens fast-spiking inhibitory neuron	spike width (ms)	0.57 ± 0.07 (7)	0.57 (ms)	Data Table
Hippocampus CA1 pyramidal cell	Hippocampus CA1 stratum pyramidale pyramidal cell	input resistance (MΩ)	226.2 ± 14.0 (15)	226.2 (MΩ)	Data Table
Hippocampus CA1 pyramidal cell	Hippocampus CA1 stratum pyramidale pyramidal cell	resting membrane potential (mV)	-74.8 ± 1.2 (15)	-74.8 (mV)	Data Table
Hippocampus CA1 pyramidal cell	Hippocampus CA1 stratum pyramidale pyramidal cell	rheobase (pA)	50.0 ± 5.9 (15)	50.0 (pA)	Data Table
Hippocampus CA1 pyramidal cell	Hippocampus CA1 stratum pyramidale pyramidal cell	spike threshold (mV)	-53.4 ± 1.2 (15)	-53.4 (mV)	Data Table
Hippocampus CA1 pyramidal cell	Hippocampus CA1 stratum pyramidale pyramidal cell	spike width (ms)	1.04 ± 0.02 (15)	1.04 (ms)	Data Table
Neocortex basket cell	Primary somatosensory cortex layer 4 fast-spiking inhibitory neuron	input resistance (MΩ)	200.1 ± 16.8 (7)	200.1 (MΩ)	Data Table
Neocortex basket cell	Primary somatosensory cortex layer 4 fast-spiking inhibitory neuron	resting membrane potential (mV)	-70.1 ± 1.4 (7)	-70.1 (mV)	Data Table
Neocortex basket cell	Primary somatosensory cortex layer 4 fast-spiking inhibitory neuron	rheobase (pA)	92.9 ± 13.0 (7)	92.9 (pA)	Data Table
Neocortex basket cell	Primary somatosensory cortex layer 4 fast-spiking inhibitory neuron	spike threshold (mV)	-54.1 ± 1.8 (7)	-54.1 (mV)	Data Table
Neocortex basket cell	Primary somatosensory cortex layer 4 fast-spiking inhibitory neuron	spike width (ms)	0.44 ± 0.04 (7)	0.44 (ms)	Data Table
Neocortex pyramidal cell layer 5-6	primary somatosensory cortex layer 5 pyramidal cell	input resistance (MΩ)	140.7 ± 11.2 (17)	140.7 (MΩ)	Data Table
Neocortex pyramidal cell layer 5-6	primary somatosensory cortex layer 5 pyramidal cell	resting membrane potential (mV)	-72.9 ± 1.1 (17)	-72.9 (mV)	Data Table
Neocortex pyramidal cell layer 5-6	primary somatosensory cortex layer 5 pyramidal cell	rheobase (pA)	107.8 ± 9.9 (17)	107.8 (pA)	Data Table
Neocortex pyramidal cell layer 5-6	primary somatosensory cortex layer 5 pyramidal cell	spike threshold (mV)	-54.7 ± 1.8 (17)	-54.7 (mV)	Data Table
Neocortex pyramidal cell layer 5-6	primary somatosensory cortex layer 5 pyramidal cell	spike width (ms)	1.02 ± 0.05 (17)	1.02 (ms)	Data Table
Thalamic reticular nucleus cell	thalamic reticular nucleus bursting GABAergic inhibitory neuron	input resistance (MΩ)	181.4 ± 14.9 (23)	181.4 (MΩ)	Data Table
Thalamic reticular nucleus cell	Thalamic reticular nucleus non-bursting GABAergic inhibitory neuron	input resistance (MΩ)	303.0 ± 47.9 (7)	303.0 (MΩ)	Data Table
Thalamic reticular nucleus cell	Thalamic reticular nucleus non-bursting GABAergic inhibitory neuron	resting membrane potential (mV)	-72.3 ± 1.7 (7)	-72.3 (mV)	Data Table
Thalamic reticular nucleus cell	thalamic reticular nucleus bursting GABAergic inhibitory neuron	resting membrane potential (mV)	-68.6 ± 3.5 (23)	-68.6 (mV)	Data Table
Thalamic reticular nucleus cell	Thalamic reticular nucleus non-bursting GABAergic inhibitory neuron	rheobase (pA)	59.3 ± 7.4 (7)	59.3 (pA)	Data Table
Thalamic reticular nucleus cell	thalamic reticular nucleus bursting GABAergic inhibitory neuron	rheobase (pA)	47.6 ± 4.5 (23)	47.6 (pA)	Data Table
Thalamic reticular nucleus cell	Thalamic reticular nucleus non-bursting GABAergic inhibitory neuron	spike threshold (mV)	-53.1 ± 0.9 (7)	-53.1 (mV)	Data Table
Thalamic reticular nucleus cell	thalamic reticular nucleus bursting GABAergic inhibitory neuron	spike threshold (mV)	-50.1 ± 4.1 (23)	-50.1 (mV)	Data Table
Thalamic reticular nucleus cell	thalamic reticular nucleus bursting GABAergic inhibitory neuron	spike width (ms)	0.65 ± 0.03 (23)	0.65 (ms)	Data Table
Thalamic reticular nucleus cell	Thalamic reticular nucleus non-bursting GABAergic inhibitory neuron	spike width (ms)	1.04 ± 0.07 (7)	1.04 (ms)	Data Table
Thalamus relay cell	Ventrobasal thalamocortical excitatory relay neuron	input resistance (MΩ)	104.5 ± 4.1 (11)	104.5 (MΩ)	Data Table
Thalamus relay cell	Ventrobasal thalamocortical excitatory relay neuron	resting membrane potential (mV)	-72.1 ± 1.0 (11)	-72.1 (mV)	Data Table
Thalamus relay cell	Ventrobasal thalamocortical excitatory relay neuron	rheobase (pA)	97.7 ± 8.6 (11)	97.7 (pA)	Data Table
Thalamus relay cell	Ventrobasal thalamocortical excitatory relay neuron	spike threshold (mV)	-57.3 ± 1.8 (11)	-57.3 (mV)	Data Table
Thalamus relay cell	Ventrobasal thalamocortical excitatory relay neuron	spike width (ms)	1.03 ± 0.02 (11)	1.03 (ms)	Data Table

Metadata values

Experimental condition	Value
Species	Mice
ElectrodeType	Patch-clamp
Strain	Mice, Inbred C57BL
PrepType	in vitro
ExternalSolution	5.0
InternalSolution	5.0
internal_1_Mg	4.0
internal_1_Na	20.3
internal_1_Cl	105.0
external_1_pH	7.3
external_1_Mg	1.0
external_1_Ca	1.0
external_1_Na	140.0
external_1_Cl	172.2
external_1_K	3.0
external_2_Mg	1.0
external_2_Ca	2.0
external_2_Na	151.25
external_2_Cl	133.5
external_2_K	2.5
internal_2_pH	7.3
internal_2_Mg	2.0
internal_2_Na	2.0
internal_2_Cl	144.0
external_3_Mg	2.0
external_3_Ca	2.0
external_3_Na	50.0
external_3_Cl	154.9
external_3_K	3.5
internal_3_Mg	2.0
internal_3_Na	12.5
internal_3_Cl	4.0
JxnPotential	Unreported
AnimalAge	14.0 - 20.0
RecTemp	34.0
internal_0_pH	7.2
internal_0_Mg	6.0
internal_0_Na	20.3
internal_0_K	130.0
internal_0_GTP	0.3
internal_0_ATP	4.0
internal_0_EGTA	10.0
internal_0_HEPES	10.0
internal_0_Cl	9.0
external_0_pH	7.4
external_0_Mg	1.0
external_0_Na	151.25
external_0_K	2.5
external_0_Cl	133.5
external_0_Ca	2.0
external_0_glucose	10.0

Data table listing

Data Table	Article Title	Authors	Journal	Year	Table needs expert?	Ephys table mentions	Curated by	Times validated
46571	Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation.	Hedrich UB; Liautard C; Kirschenbaum D; Pofahl M; Lavigne J; Liu Y; Theiss S; Slotta J; Escayg A; Dihné M; Beck H; Mantegazza M; Lerche H	J. Neurosci.	2014	False	5	Kerrie Tsigounis, Patrick Savage,	1
46573	Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation.	Hedrich UB; Liautard C; Kirschenbaum D; Pofahl M; Lavigne J; Liu Y; Theiss S; Slotta J; Escayg A; Dihné M; Beck H; Mantegazza M; Lerche H	J. Neurosci.	2014	False	2		0
46572	Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation.	Hedrich UB; Liautard C; Kirschenbaum D; Pofahl M; Lavigne J; Liu Y; Theiss S; Slotta J; Escayg A; Dihné M; Beck H; Mantegazza M; Lerche H	J. Neurosci.	2014	False	0		None