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Article: Three Types of Cortical Layer 5 Neurons That Differ in Brain-wide Connectivity and Function.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Kim EJ; Juavinett AL; Kyubwa EM; Jacobs MW; Callaway EM
Neuron, 2015

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron adaptation ratio 0.443 ± 0.086 (9) 0.443 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron adaptation ratio 0.568 ± 0.024 (17) 0.568 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron adaptation ratio 0.197 ± 0.024 (11) 0.197 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron adaptation ratio (other) 0.03 ± 0.009 (9) 0.03 (None) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron adaptation ratio (other) 0.026 ± 0.003 (17) 0.026 (None) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron adaptation ratio (other) 0.036 ± 0.007 (11) 0.036 (None) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron cell capacitance (pF) 159.4 ± 18.49 (5) 159.4 (pF) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron cell capacitance (pF) 19.77 ± 3.348 (7) 19.77 (pF) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron cell capacitance (pF) 26.3 ± 1.907 (6) 26.3 (pF) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron input resistance (MΩ) 120.908 ± 6.678 (17) 120.908 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron input resistance (MΩ) 146.365 ± 14.527 (11) 146.365 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron input resistance (MΩ) 263.372 ± 52.722 (9) 263.372 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron resting membrane potential (mV) -65.67 ± 2.02 (16) -65.67 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron resting membrane potential (mV) -60.68 ± 1.55 (9) -60.68 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron resting membrane potential (mV) -57.29 ± 1.38 (9) -57.29 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron sag amplitude (mV) 11.6 ± 1.07 (9) 11.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron sag amplitude (mV) 2.46 ± 0.37 (16) 2.46 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron sag amplitude (mV) 10.99 ± 1.57 (9) 10.99 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron sag ratio 20.93 ± 2.05 (9) 0.2093 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron sag ratio 6.57 ± 0.88 (16) 0.0657 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron sag ratio 22.19 ± 1.34 (9) 0.2219 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron spike amplitude (mV) 68.32 ± 3.89 (9) 68.32 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron spike amplitude (mV) 74.52 ± 2.96 (17) 74.52 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron spike amplitude (mV) 73.22 ± 2.32 (11) 73.22 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron spike decay time (mV/s) -29.92 ± 2.28 (11) -- Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron spike decay time (mV/s) -32.14 ± 6.57 (9) -- Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron spike decay time (mV/s) -35.25 ± 3.11 (17) -- Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron spike half-width (ms) 2.48 ± 0.22 (11) 2.48 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron spike half-width (ms) 2.35 ± 0.25 (9) 2.35 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron spike half-width (ms) 2.8 ± 0.47 (17) 2.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron spike rise time (mV/s) 119.5 ± 19.24 (9) -- Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron spike rise time (mV/s) 162.4 ± 14.35 (17) -- Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron spike rise time (mV/s) 123.54 ± 8.46 (11) -- Data Table

Report miscurated data

Metadata values

Experimental condition Value
ElectrodeType Patch-clamp
AnimalAge 28.0 - 50.0
Species Mice
Strain Mouse, Transgenic
PrepType in vitro
JxnPotential Unreported
RecTemp 20.0 - 24.0
InternalSolution 5.0
ExternalSolution 5.0
internal_0_pH 7.3
internal_0_Mg 4.0
internal_0_Na 0.3
internal_0_K 137.0
internal_0_GTP 0.3
internal_0_ATP 4.0
internal_0_EGTA 0.5
internal_0_HEPES 10.0
internal_0_Cl 7.0
external_0_Mg 1.0
external_0_Na 156.0
external_0_K 3.75
external_0_Cl 129.5
external_0_Ca 2.0
external_0_glucose 20.0
external_0_CNQX 3.0
external_0_DAPV 250.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
48877 Three Types of Cortical Layer 5 Neurons That Differ in Brain-wide Connectivity and Function. Kim EJ; Juavinett AL; Kyubwa EM; Jacobs MW; Callaway EM Neuron 2015 False 11 Shreejoy Tripathy, Kerrie Tsigounis, James liu, Patrick Savage, 2