Article: Altered purinergic signaling in colorectal dorsal root ganglion neurons contributes to colorectal hypersensitivity.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Shinoda M; La JH; Bielefeldt K; Gebhart GF
J. Neurophysiol., 2010

Table 2.

Passive and active electrical properties of LS and TL colon neurons from zymosan-treated and control (saline-treated) mice

Property	Treatment	TL		LS
A. Current injection
Whole cell capacitance, pF	Control	33.0 ± 1.7 (37)		33.5 ± 1.3 (35)
	Zymosan	28.9 ± 1.2 (25)		34.8 ± 1.3 (37)
Series resistance, mohm	Control	6.0 ± 0.3 (37)		6.5 ± 0.3 (35)
	Zymosan	6.3 ± 0.5 (25)		6.3 ± 0.3 (37)
Resting membrane potential, mV	Control	^*−63.5 ± 1.4 (37)		−64.3 ± 1.4 (35)^*
	Zymosan	^*−58.4 ± 1.9 (25)		−57.9 ± 1.6 (37)^*
Spontaneous activity (frequency)	Control	0/37		0/35^*
	Zymosan	1/25		6/37^*
AP threshold, mV	Control	−27.6 ± 1.2 (31)		−28.9 ± 1.2 (24)
	Zymosan	−29.8 ± 1.3 (16)		−29.4 ± 1.4 (26)
Rheobase, pA	Control	247.3 ± 13.0 (37)		227.1 ± 21.7 (24)
	Zymosan	237.5 ± 23.5 (16)		211.5 ± 16.5 (26)
AP@2× rheobase (frequency)	Control	2.8 ± 0.8 (31)		4.4 ± 0.9 (23)
	Zymosan	4.8 ± 1.4 (16)		5.4 ± 1.1 (26)
Input resistance, mohm	Control	−32.4 ± 3.6 (32)		−40.1 ± 3.3 (26)
	Zymosan	−28.8 ± 3.8 (16)		−35.9 ± 3.7 (26)
B. ATP (30 μM)
Number of cells which induce AP, %	Control	^*2.9 (1/34)		5.7 (2/35)
	Zymosan	^*20 (4/20)		16.8 (5/30)
Number of cells depolarized, %	Control	50 (17/34)		52.6 (20/38)
	Zymosan	75 (15/20)		67.7 (21/31)
Depolazation, mV	Control	16.8 ± 2.7 (17)		13.9 ± 1.5 (20)
	Zymosan	16.9 ± 1.7 (15)		17.1 ± 1.8 (21)
C. α,β-meATP (30 μM)
Number of cells which induce AP, %	Control	0 (0/32)		0 (0/31)
	Zymosan	10 (2/20)	—^*	0 (0/25)
Number of cells depolarized, %	Control	50 (16/32)		25.8 (8/31)^*
	Zymosan	70 (14/20)	—^*	60 (15/25)^*
Depolazation, mV	Control	15.7 ± 2.0 (16)		9.5 ± 1.5 (8)
	Zymosan	17.2 ± 1.7 (15)		11.3 ± 1.5 (15)

Values are means ± SE, or percentages. Number of neurons are in parentheses.
↵* P < 0.05. AP, action potential, ATP, adenosine-5′-triphosphate; α,β-meATP, α,β-m ethylene ATP.

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Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Dorsal root ganglion cell	thoracolumbar colorectal dorsal root ganglion cell	rheobase (pA)	247.3 ± 13.0	247.3 (pA)	Data Table
Dorsal root ganglion cell	lumbosacral colorectal dorsal root ganglion cell	rheobase (pA)	227.1 ± 21.7	227.1 (pA)	Data Table
Dorsal root ganglion cell	thoracolumbar colorectal dorsal root ganglion cell	input resistance (mohm)	-32.4 ± 3.6	--	Data Table
Dorsal root ganglion cell	lumbosacral colorectal dorsal root ganglion cell	input resistance (mohm)	-40.1 ± 3.3	--	Data Table
Dorsal root ganglion cell	thoracolumbar colorectal dorsal root ganglion cell	cell capacitance (pF)	33.0 ± 1.7	33.0 (pF)	Data Table
Dorsal root ganglion cell	lumbosacral colorectal dorsal root ganglion cell	cell capacitance (pF)	33.5 ± 1.3	33.5 (pF)	Data Table
Dorsal root ganglion cell	thoracolumbar colorectal dorsal root ganglion cell	access resistance (mohm)	6.0 ± 0.3	6e-09 (MΩ)	Data Table
Dorsal root ganglion cell	lumbosacral colorectal dorsal root ganglion cell	access resistance (mohm)	6.5 ± 0.3	6.5e-09 (MΩ)	Data Table
Dorsal root ganglion cell	thoracolumbar colorectal dorsal root ganglion cell	resting membrane potential (mV)	-63.5 ± 1.4	-63.5 (mV)	Data Table
Dorsal root ganglion cell	lumbosacral colorectal dorsal root ganglion cell	resting membrane potential (mV)	-64.3 ± 1.4	-64.3 (mV)	Data Table
Dorsal root ganglion cell	thoracolumbar colorectal dorsal root ganglion cell	spike threshold (mV)	-27.6 ± 1.2	-27.6 (mV)	Data Table
Dorsal root ganglion cell	lumbosacral colorectal dorsal root ganglion cell	spike threshold (mV)	-28.9 ± 1.2	-28.9 (mV)	Data Table