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Article: Functional role of A-type potassium currents in rat presympathetic PVN neurones.

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Sonner PM; Stern JE
J. Physiol. (Lond.), 2007


Table 1. The effects of 4-AP upon action potential waveform parameters

4-AP stimulated group 4-AP inhibited group
ACSF 5 mm 4-AP ACSF 5 mm 4-AP
P < 0.05 within same group; †P < 0.05 between different groups (same drug treatment). IA restrains firing activity in a subset of PVN-RVLM neurones.
Peak amplitude (mV) 64.6 ± 1.4   70.3 ± 1.3*   61.1 ± 2.7    67.8 ± 3.1*  
Half-width (ms) 3.0 ± 0.09 5.1 ± 0.3 * 4.1 ± 0.2†  7.5 ± 0.6*†
90–10% decay time (ms) 1.5 ± 0.06 2.9 ± 0.2*  2.0 ± 0.08† 5.2 ± 0.6*†
Threshold (mV) −31.2 ± 0.8     − 32.8 ± 0.8*    −31.0 ± 0.9     −31.8 ± 1.7    

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Paraventricular hypothalamic nucleus neurons paraventricular hypothalamic nucleus 4-aminopyridine inhibited neurons projecting to rostral ventrolateral medulla spike half-width (ms) 4.1 ± 0.2 (12) -- Data Table
Paraventricular hypothalamic nucleus neurons paraventricular hypothalamic nucleus 4-aminopyridine stimulated neurons projecting to rostral ventrolateral medulla spike decay time (ms) 1.5 ± 0.06 (23) -- Data Table
Paraventricular hypothalamic nucleus neurons paraventricular hypothalamic nucleus 4-aminopyridine inhibited neurons projecting to rostral ventrolateral medulla spike decay time (ms) 2.0 ± 0.08 (12) -- Data Table
Paraventricular hypothalamic nucleus neurons paraventricular hypothalamic nucleus 4-aminopyridine stimulated neurons projecting to rostral ventrolateral medulla spike threshold (mV) -31.2 ± 0.8 (23) -- Data Table
Paraventricular hypothalamic nucleus neurons paraventricular hypothalamic nucleus 4-aminopyridine inhibited neurons projecting to rostral ventrolateral medulla spike threshold (mV) -31.0 ± 0.9 (12) -- Data Table
Paraventricular hypothalamic nucleus neurons paraventricular hypothalamic nucleus 4-aminopyridine stimulated neurons projecting to rostral ventrolateral medulla spike amplitude (mV) 64.6 ± 1.4 (23) -- Data Table
Paraventricular hypothalamic nucleus neurons paraventricular hypothalamic nucleus 4-aminopyridine inhibited neurons projecting to rostral ventrolateral medulla spike amplitude (mV) 61.1 ± 2.7 (12) -- Data Table
Paraventricular hypothalamic nucleus neurons paraventricular hypothalamic nucleus 4-aminopyridine stimulated neurons projecting to rostral ventrolateral medulla spike half-width (ms) 3.0 ± 0.09 (23) -- Data Table