Properties of mIPSCs in dentate granule cells after pilocarpine-induced status epilepticus
| CGC | GC-SE | HEGC | |
|---|---|---|---|
| Frequency, Hz | 1.44 ± 0.21 | 1.19 ± 0.25 | 0.34 ± 0.06*† |
| Interevent interval, s | 0.69 ± 0.02 | 0.91 ± 0.04‡ | 2.69 ± 0.22‡§ |
| Amplitude, pA | 27.61 ± 0.55 | 30.24 ± 0.85‡ | 30.78 ± 1.40‡ |
| 10–90% rise time, ms | 1.71 ± 0.03 | 2.05 ± 0.04‡ | 2.39 ± 0.07‡§ |
| τ, ms | 8.66 ± 0.16 | 8.44 ± 0.17 | 10.80 ± 0.46‡§ |
| Charge transfer, fC | 226 ± 7 | 271 ± 10¶ | 358 ± 25‡§ |
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Values are means ± SE. mIPSC frequency was determined for 6 (CGC and GC-SE) or 7 (HEGC) cells per group. Other parameters were determined for 1,293 (CGC), 1,073 (GC-SE), or 362 (HEGC) events recorded from the indicated number of cells. mIPSCs were recorded in the presence of 10 μM NBQX, 50 μM D-AP5, and 1 μM TTX for 2.5 min at 22–24°C. Recordings were made with a CsCl-based internal solution at a holding potential of −70 mV.
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↵* Significantly different from CGC at P < 0.01 (Newman-Keuls test after 1-way ANOVA yielded P < 0.005).
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↵† Significantly different from GC-SE at P < 0.01 (Newman-Keuls test).
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↵‡ Significantly different from CGC at P < 0.001 (Kolmogorov-Smirnov test).
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↵§ Significantly different from GC-SE at P < 0.001 (Kolmogorov-Smirnov test).
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↵¶ Significantly different from CGC at P < 0.005 (Kolmogorov-Smirnov test). mIPSC, miniature inhibitory posysynaptic current. See Table 1 for other abbreviations.