Table 1.
Electrophysiological properties of CA3 neurons after reperfusion
| RMP, mV | Spike | Spike Width, ms | Rin, MΩ | Time | Spontaneous Firing, Hz | |
|---|---|---|---|---|---|---|
| Height, mV | Constant, ms | |||||
| Before ischemia | −66 ± 5.5 | 75 ± 9.7 | 0.76 ± 0.15 | 26.6 ± 8.5 | 15.2 ± 7.6 | 1.28 ± 1.38 |
| (19) | (22) | (22) | (17) | (17) | (10) | |
| ∼6 h after reperfusion | −61 ± 6.1* | 78 ± 8.7 | 0.89 ± 0.26* | 20.7 ± 5.0 | 10.9 ± 4.8 | 0.83 ± 1.29 |
| (11) | (14) | (14) | (9) | (9) | (10) | |
| ∼21 h after reperfusion | −64 ± 4.6 | 77 ± 5.8 | 0.76 ± 0.07 | 23.8 ± 1.7 | 13.2 ± 4.5 | 0.65 ± 1.31 |
| (11) | (10) | (10) | (9) | (9) | (10) | |
| ∼29 h after reperfusion | −64 ± 3.2 | 75 ± 7.9 | 0.73 ± 0.08 | 29.0 ± 12.8 | 17.3 ± 7.4 | 2.13 ± 3.56 |
| (12) | (15) | (15) | (10) | (10) | (8) | |
| ∼43 h after reperfusion | −66 ± 4.6 | 76 ± 10.4 | 0.77 ± 0.11 | 29.3 ± 10.9 | 14.3 ± 8.5 | 1.11 ± 1.82 |
| (15) | (17) | (17) | (16) | (16) | (10) | |
| 7 d after reperfusion | −65 ± 2.5 | 76 ± 10.8 | 0.82 ± 0.09 | 32.6 ± 7.8 | 12.1 ± 2.3 | 1.34 ± 1.01 |
| (10) | (10) | (10) | (8) | (8) | (7) |
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Values are means ± SD with number of neurons in parentheses. Spike height is measured from the resting membrane potential. Spike width is measured at one-half of the peak amplitude of the action potential. Input resistance (R in) is derived from the linear portion of the current-voltage curve (0 to −0.5 nA). Time constant is derived from transients of hyperpolarizing pulse (−0.3 nA, 200 ms). RMP, resting membrane potential.
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↵* P < 0.01, analysis of variance.