Table 2.
Electrophysiological properties of granule cells after reperfusion
| RMP, mV | Spike | Spike Width, ms | Rin, MΩ | Time | Spontaneous Firing, Hz | |
|---|---|---|---|---|---|---|
| Height, mV | Constant, ms | |||||
| Before ischemia | −71 ± 6.2 | 85 ± 11.5 | 0.80 ± 0.12 | 44.2 ± 13.7 | 9.8 ± 6.7 | 0.19 ± 0.50 |
| (15) | (15) | (15) | (11) | (11) | (15) | |
| ∼4 h after reperfusion | −77 ± 10.2 | 89 ± 13.1 | 0.92 ± 0.16* | 46.2 ± 9.3 | 8.5 ± 2.8 | 0.12 ± 0.42 |
| (12) | (13) | (13) | (9) | (9) | (12) | |
| ∼19 h after reperfusion | −73 ± 9.6 | 79 ± 16.7 | 0.78 ± 0.12 | 44.0 ± 14.0 | 14.2 ± 8.8 | 0.00 ± 0.00 |
| (17) | (16) | (16) | (13) | (13) | (13) | |
| ∼31 h after reperfusion | −72 ± 5.3 | 82 ± 11.8 | 0.88 ± 0.23 | 26.3 ± 19.1† | 7.8 ± 3.8 | 0.00 ± 0.00 |
| (12) | (9) | (9) | (11) | (11) | (9) | |
| ∼44 h after reperfusion | −72 ± 6.9 | 80 ± 7.8 | 0.85 ± 0.20 | 35.0 ± 12.8 | 9.1 ± 6.8 | 0.20 ± 0.64 |
| (16) | (19) | (19) | (12) | (12) | (13) | |
| 7 d after reperfusion | −76 ± 6.3 | 84 ± 7.8 | 0.83 ± 0.09 | 44.1 ± 12.4 | 13.9 ± 5.2 | 0.14 ± 0.38 |
| (7) | (7) | (7) | (7) | (7) | (7) |
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Values are means ± SD with number of neurons in parentheses. Spike height is measured from the resting membrane potential. Spike width is measured at one-half of the peak amplitude of the action potential. Input resistance (R in) is derived from the linear portion of the current-voltage curve (0 to −0.5 nA). Time constant is derived from transients of hyperpolarizing pulse (−0.3 nA, 200 ms). RMP, resting membrane potential.
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↵* P < 0.05.
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↵† P < 0.01, analysis of variance.