Characteristics of deep layer EC intracellular evoked responses
Control | Epileptic | |
---|---|---|
n * | 30 | 44 |
Total duration of depolarization, ms | 8.6 ± 1.3 | 256 ± 39† |
Number of APs per response | 1 ± 0 | 13 ± 4† |
Clonic response present, % | 0 | 10‡ |
With GABAA and GABAB IPSPs,ρ % | 77 | 0‡ |
With GABAA IPSP only,ρ % | 13 | 0‡ |
Without IPSPs, % | 10 | 100‡ |
AP stimulation threshold to angular bundle stimulation, V | 40 ± 6.0 | 21 ± 6.17 |
AP stimulation threshold to superficial stimulation, V | 7.8 ± 3.4 | 6.8 ± 1.8 |
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Values for continuous variable are means ± SE. Continuous variables compared by ANOVA and proportions compared by Fisher's exact test. AP, action potential; GABAA and GABAB, γ-amino butyric acid-A and -B.
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↵* n, number of responses with the given inhibitory postsynaptic potential (IPSP). † Difference between control and epileptic is statistically significant at P < 0.05. ‡ Difference between control and epileptic is statistically significant at P < 0.001. ρ GABAA and GABAB are early and late IPSPs, respectively.