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Article: Early exposure to alcohol leads to permanent impairment of dendritic excitability in neocortical pyramidal neurons.

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Granato A; Palmer LM; De Giorgio A; Tavian D; Larkum ME
J. Neurosci., 2012


Table 1.

Main electrophysiological properties of layer 5 pyramidal neurons

Control Ethanol F(1,10) p
Number of animals 7 5
Number of neurons 19 19
Resting membrane potential (mV) −72.69 ± 1.01 −73.67 ± 1.77 0.02 0.905
Input resistance (MΩ) 23.31 ± 1.79 22.54 ± 1.10 0.00 0.964
Membrane time constant (ms) 11.43 ± 0.84 13.12 ± 1.17 0.53 0.482
Rheobase (pA) 726.32 ± 43.15 705.26 ± 42.90 0.46 0.512
Absolute threshold (mV) −42.56 ± 0.82 −41.78 ± 1.28 0.02 0.892
Spike amplitude (mV) 87.46 ± 0.75 87.15 ± 0.91 0.09 0.775
Spike half-width (ms) 0.63 ± 0.02 0.72 ± 0.04 0.50 0.496
Fast AHP (mV) −7.77 ± 0.43 −7.27 ± 0.71 0.09 0.772
Slow AHP (mV) −12.86 ± 0.56 −11.25 ± 0.54 1.96 0.192

  • Subthreshold and suprathreshold properties of Co and Et layer 5 pyramidal neurons, as observed after injection of 1 s steps of current at soma. AHP, Afterhyperpolarization.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5b pyramidal cell resting membrane potential (mV) -72.69 ± 1.01 (19) -72.69 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5b pyramidal cell input resistance (MΩ) 23.31 ± 1.79 (19) 23.31 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5b pyramidal cell membrane time constant (ms) 11.43 ± 0.84 (19) 11.43 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5b pyramidal cell rheobase (pA) 726.32 ± 43.15 (19) 726.32 (pA) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5b pyramidal cell spike threshold (mV) -42.56 ± 0.82 (19) -42.56 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5b pyramidal cell spike amplitude (mV) 87.46 ± 0.75 (19) 87.46 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5b pyramidal cell spike half-width (ms) 0.63 ± 0.02 (19) 0.63 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5b pyramidal cell fast AHP amplitude (mV) -7.77 ± 0.43 (19) 7.77 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5b pyramidal cell slow AHP amplitude (mV) -12.86 ± 0.56 (19) 12.86 (mV) Data Table