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Article: The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Lee S; Hjerling-Leffler J; Zagha E; Fishell G; Rudy B J. Neurosci., 2010
Table 1.
Quantification of electrophysiological properties of 5-HT3AR-expressing neurons in layer 2/3 (n = 80)
| LS1 | LS2 | bNA1 | bNA2 | IS | dNFS3 | fAD | |
|---|---|---|---|---|---|---|---|
| RMP (mV) | −61.2 ± 5.8 | −60.5 ± 7.0 | −63 ± 4.3 | −60.2 ± 5.7 | −58.4 ± 5.9 | −65 ± 6.3 | −56.9 ± 7.0 |
| R m (MΩ) | 329 ± 89 | 285 ± 101 | 332 ± 124 | 369 ± 143 | 406 ± 132 | 631 ± 310 | 459 ± 179 |
| τm (ms) | 17.3 ± 6.5 | 19.3 ± 5.8 | 17.5 ± 8.5 | 19.4 ± 8.3 | 20.1 ± 7.1 | 27.7 ± 12.3 | 26.4 ± 9.7 |
| Spike threshold (mV) | −38.2 ± 5.4 | −36.9 ± 5.1 | −35.5 ± 4.5 | −36.1 ± 3.8 | −39.8 ± 6.3 | −42.2 ± 6.1 | −38.3 ± 4.9 |
| Spike width (ms) | 1.4 ± 0.5 | 1.4 ± 0.4 | 1.4 ± 0.6 | 1.4 ± 0.4 | 1.2 ± 0.4 | 1.3 ± 0.3 | 1.1 ± 0.3 |
| AHP amplitude (mV) | −19.3 ± 5.2 | −18.2 ± 3.9 | −16.1 ± 5.1 | −14.4 ± 4.6 | −13.0 ± 0.4 | −15.3 ± 3.3 | −12.2 ± 3.4 |
| tAHP (ms) | 23.1 ± 4.8 | 24.8 ± 7.9 | 50.3 ± 11.9 | 24.9 ± 8.5 | 14.2 ± 5.2 | 14.1 ± 9.8 | 18.1 ± 9.9 |
| Delay to spike (ms) | 376.3 ± 79.8 | 224.8 ± 130.1 | 70.3 ± 21.4 | 75.4 ± 41.4 | 259.5 ± 120.5 | 14.1 ± 9.8 | 18.1 ± 9.9 |
| Max frequency (Hz) | 79.3 ± 30.1 | 59.2 ± 18.4 | 52.6 ± 14.9 | 61.5 ± 28.4 | 84.9 ± 16.5 | 81.3 ± 21.4 | 85.7 ± 21.5 |
| Adaptation (%) | 51.3 ± 14.5 | 53.9 ± 16.3 | 63.7 ± 18.2 | 59.4 ± 21.4 | 41.5 ± 11.6 | 36.3 ± 9.8 | N/A |
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For an explanation of the parameters, see Materials and Methods.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic late-spiking subtype 1 Htr3a-expressing interneuron | input resistance (MΩ) | 329.0 ± 89.0 (45) | 329.0 (MΩ) | Data Table |
| Other | neocortex layer 2/3 GABAergic late-spiking subtype 2 Htr3a-expressing interneuron | input resistance (MΩ) | 285.0 ± 101.0 (15) | 285.0 (MΩ) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 1 Htr3a-expressing interneuron | input resistance (MΩ) | 332.0 ± 124.0 (18) | 332.0 (MΩ) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 2 Htr3a-expressing interneuron | input resistance (MΩ) | 369.0 ± 143.0 (5) | 369.0 (MΩ) | Data Table |
| Other | neocortex layer 2/3 GABAergic irregular spiking bipolar Htr3a-expressing interneuron | input resistance (MΩ) | 406.0 ± 132.0 (30) | 406.0 (MΩ) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic delayed non-fast-spiking Htr3a-expressing interneuron | input resistance (MΩ) | 631.0 ± 310.0 (3) | 631.0 (MΩ) | Data Table |
| Other | neocortex layer 2/3 GABAergic fast-adapting Htr3a-expressing interneuron | input resistance (MΩ) | 459.0 ± 179.0 (16) | 459.0 (MΩ) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic late-spiking subtype 1 Htr3a-expressing interneuron | membrane time constant (ms) | 17.3 ± 6.5 (45) | 17.3 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic late-spiking subtype 2 Htr3a-expressing interneuron | membrane time constant (ms) | 19.3 ± 5.8 (15) | 19.3 (ms) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic late-spiking subtype 1 Htr3a-expressing interneuron | resting membrane potential (mV) | -61.2 ± 5.8 (45) | -61.2 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 1 Htr3a-expressing interneuron | membrane time constant (ms) | 17.5 ± 8.5 (18) | 17.5 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 2 Htr3a-expressing interneuron | membrane time constant (ms) | 19.4 ± 8.3 (5) | 19.4 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic irregular spiking bipolar Htr3a-expressing interneuron | membrane time constant (ms) | 20.1 ± 7.1 (30) | 20.1 (ms) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic delayed non-fast-spiking Htr3a-expressing interneuron | membrane time constant (ms) | 27.7 ± 12.3 (3) | 27.7 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic fast-adapting Htr3a-expressing interneuron | membrane time constant (ms) | 26.4 ± 9.7 (16) | 26.4 (ms) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic late-spiking subtype 1 Htr3a-expressing interneuron | spike threshold (mV) | -38.2 ± 5.4 (45) | -38.2 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic late-spiking subtype 2 Htr3a-expressing interneuron | spike threshold (mV) | -36.9 ± 5.1 (15) | -36.9 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 1 Htr3a-expressing interneuron | spike threshold (mV) | -35.5 ± 4.5 (18) | -35.5 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 2 Htr3a-expressing interneuron | spike threshold (mV) | -36.1 ± 3.8 (5) | -36.1 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic late-spiking subtype 2 Htr3a-expressing interneuron | resting membrane potential (mV) | -60.5 ± 7.0 (15) | -60.5 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic irregular spiking bipolar Htr3a-expressing interneuron | spike threshold (mV) | -39.8 ± 6.3 (30) | -39.8 (mV) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic delayed non-fast-spiking Htr3a-expressing interneuron | spike threshold (mV) | -42.2 ± 6.1 (3) | -42.2 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic fast-adapting Htr3a-expressing interneuron | spike threshold (mV) | -38.3 ± 4.9 (16) | -38.3 (mV) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic late-spiking subtype 1 Htr3a-expressing interneuron | spike half-width (ms) | 1.4 ± 0.5 (45) | 1.4 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic late-spiking subtype 2 Htr3a-expressing interneuron | spike half-width (ms) | 1.4 ± 0.4 (15) | 1.4 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 1 Htr3a-expressing interneuron | spike half-width (ms) | 1.4 ± 0.6 (18) | 1.4 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 2 Htr3a-expressing interneuron | spike half-width (ms) | 1.4 ± 0.4 (5) | 1.4 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic irregular spiking bipolar Htr3a-expressing interneuron | spike half-width (ms) | 1.2 ± 0.4 (30) | 1.2 (ms) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic delayed non-fast-spiking Htr3a-expressing interneuron | spike half-width (ms) | 1.3 ± 0.3 (3) | 1.3 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 1 Htr3a-expressing interneuron | resting membrane potential (mV) | -63.0 ± 4.3 (18) | -63.0 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic fast-adapting Htr3a-expressing interneuron | spike half-width (ms) | 1.1 ± 0.3 (16) | 1.1 (ms) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic late-spiking subtype 1 Htr3a-expressing interneuron | AHP amplitude (mV) | -19.3 ± 5.2 (45) | 19.3 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic late-spiking subtype 2 Htr3a-expressing interneuron | AHP amplitude (mV) | -18.2 ± 3.9 (15) | 18.2 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 1 Htr3a-expressing interneuron | AHP amplitude (mV) | -16.1 ± 5.1 (18) | 16.1 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 2 Htr3a-expressing interneuron | AHP amplitude (mV) | -14.4 ± 4.6 (5) | 14.4 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic irregular spiking bipolar Htr3a-expressing interneuron | AHP amplitude (mV) | -13.0 ± 0.4 (30) | 13.0 (mV) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic delayed non-fast-spiking Htr3a-expressing interneuron | AHP amplitude (mV) | -15.3 ± 3.3 (3) | 15.3 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic fast-adapting Htr3a-expressing interneuron | AHP amplitude (mV) | -12.2 ± 3.4 (16) | 12.2 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 2 Htr3a-expressing interneuron | resting membrane potential (mV) | -60.2 ± 5.7 (5) | -60.2 (mV) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic late-spiking subtype 1 Htr3a-expressing interneuron | AHP duration (ms) | 23.1 ± 4.8 (45) | 23.1 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic late-spiking subtype 2 Htr3a-expressing interneuron | AHP duration (ms) | 24.8 ± 7.9 (15) | 24.8 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 1 Htr3a-expressing interneuron | AHP duration (ms) | 50.3 ± 11.9 (18) | 50.3 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 2 Htr3a-expressing interneuron | AHP duration (ms) | 24.9 ± 8.5 (5) | 24.9 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic irregular spiking bipolar Htr3a-expressing interneuron | AHP duration (ms) | 14.2 ± 5.2 (30) | 14.2 (ms) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic delayed non-fast-spiking Htr3a-expressing interneuron | AHP duration (ms) | 14.1 ± 9.8 (3) | 14.1 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic fast-adapting Htr3a-expressing interneuron | AHP duration (ms) | 18.1 ± 9.9 (16) | 18.1 (ms) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic late-spiking subtype 1 Htr3a-expressing interneuron | first spike latency (ms) | 376.3 ± 79.8 (45) | 376.3 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic late-spiking subtype 2 Htr3a-expressing interneuron | first spike latency (ms) | 224.8 ± 130.1 (15) | 224.8 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic irregular spiking bipolar Htr3a-expressing interneuron | resting membrane potential (mV) | -58.4 ± 5.9 (30) | -58.4 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 1 Htr3a-expressing interneuron | first spike latency (ms) | 70.3 ± 21.4 (18) | 70.3 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 2 Htr3a-expressing interneuron | first spike latency (ms) | 75.4 ± 41.4 (5) | 75.4 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic irregular spiking bipolar Htr3a-expressing interneuron | first spike latency (ms) | 259.5 ± 120.5 (30) | 259.5 (ms) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic delayed non-fast-spiking Htr3a-expressing interneuron | first spike latency (ms) | 14.1 ± 9.8 (3) | 14.1 (ms) | Data Table |
| Other | neocortex layer 2/3 GABAergic fast-adapting Htr3a-expressing interneuron | first spike latency (ms) | 18.1 ± 9.9 (16) | 18.1 (ms) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic late-spiking subtype 1 Htr3a-expressing interneuron | maximum firing rate (Hz) | 79.3 ± 30.1 (45) | 79.3 (Hz) | Data Table |
| Other | neocortex layer 2/3 GABAergic late-spiking subtype 2 Htr3a-expressing interneuron | maximum firing rate (Hz) | 59.2 ± 18.4 (15) | 59.2 (Hz) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 1 Htr3a-expressing interneuron | maximum firing rate (Hz) | 52.6 ± 14.9 (18) | 52.6 (Hz) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 2 Htr3a-expressing interneuron | maximum firing rate (Hz) | 61.5 ± 28.4 (5) | 61.5 (Hz) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic delayed non-fast-spiking Htr3a-expressing interneuron | resting membrane potential (mV) | -65.0 ± 6.3 (3) | -65.0 (mV) | Data Table |
| Other | neocortex layer 2/3 GABAergic irregular spiking bipolar Htr3a-expressing interneuron | maximum firing rate (Hz) | 84.9 ± 16.5 (30) | 84.9 (Hz) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic delayed non-fast-spiking Htr3a-expressing interneuron | maximum firing rate (Hz) | 81.3 ± 21.4 (3) | 81.3 (Hz) | Data Table |
| Other | neocortex layer 2/3 GABAergic fast-adapting Htr3a-expressing interneuron | maximum firing rate (Hz) | 85.7 ± 21.5 (16) | 85.7 (Hz) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic late-spiking subtype 1 Htr3a-expressing interneuron | adaptation percent (1 – first/last ISI) | 51.3 ± 14.5 (45) | 51.3 (ratio) | Data Table |
| Other | neocortex layer 2/3 GABAergic late-spiking subtype 2 Htr3a-expressing interneuron | adaptation percent (1 – first/last ISI) | 53.9 ± 16.3 (15) | 53.9 (ratio) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 1 Htr3a-expressing interneuron | adaptation percent (1 – first/last ISI) | 63.7 ± 18.2 (18) | 63.7 (ratio) | Data Table |
| Other | neocortex layer 2/3 GABAergic burst non-adapting subtype 2 Htr3a-expressing interneuron | adaptation percent (1 – first/last ISI) | 59.4 ± 21.4 (5) | 59.4 (ratio) | Data Table |
| Other | neocortex layer 2/3 GABAergic irregular spiking bipolar Htr3a-expressing interneuron | adaptation percent (1 – first/last ISI) | 41.5 ± 11.6 (30) | 41.5 (ratio) | Data Table |
| Neocortex uncharacterized cell | neocortex layer 2/3 GABAergic delayed non-fast-spiking Htr3a-expressing interneuron | adaptation percent (1 – first/last ISI) | 36.3 ± 9.8 (3) | 36.3 (ratio) | Data Table |
| Other | neocortex layer 2/3 GABAergic fast-adapting Htr3a-expressing interneuron | resting membrane potential (mV) | -56.9 ± 7.0 (16) | -56.9 (mV) | Data Table |