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Article: Diversification of intrinsic motoneuron electrical properties during normal development and botulinum toxin-induced muscle paralysis in early postnatal mice.

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Nakanishi ST; Whelan PJ
J. Neurophysiol., 2010


Table 2.

Motoneuron electrical properties recorded from untreated, control extensor motoneurons (P0–P3) control, (P8–P11), and botulinum toxin (BTX)–treated (P8–P11) extensor motoneurons

Control P0–P3 (n = 16) Control P8–P11 (n = 14) BTX P8–P11 (n = 16)
Property Mean SE Mean SE Mean SE P Value
Action potential
    Amplitude, mV 79.67 1.98 72.62 3.63 71.57 2.23 NS (0.06)
    Half-width, ms 1.34 0.18 1.53 0.13 1.14 0.08 NS (0.15)
    Time-to-peak, ms 0.87 0.06 1.31 0.15 0.91 0.05 <0.01*
    Threshold, mV −51.67 1.94 −54.41 2.16 −58.09 2.01 NS (0.08)
Rheobase current, pA 133.50 14.54 139.00 20.54 252.40 46.31 <0.05*
    Rheobase current CV, % 54.55 59.18 72.98 NS (0.57)
Afterhyperpolarization
    Half-decay time, ms 40.77 4.94 48.32 4.96 39.39 4.30 NS (0.43)
    Half-decay time CV, % 39.33 36.66 47.11 NS (0.78)
Input resistance (Rin), MΩ 158.30 27.41 156.20 26.89 72.31 9.46 <0.05*
    Rin CV, % 77.41 69.52 54.04 NS (0.50)
f–I gain, Hz/nA 57.41 7.16 71.19 9.41 63.91 13.31 NS (0.54)
    f–I gain CV, % 45.34 39.49 47.47 NS (0.78)

  • n = number of motoneurons. CV, coefficient of variation.

  • ↵* indicates significance; NS, not significant.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron spike amplitude (mV) 79.67 (16) 79.67 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron spike amplitude (mV) 72.62 (14) 72.62 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron spike half-width (ms) 1.34 (16) 1.34 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron spike half-width (ms) 1.53 (14) 1.53 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron spike rise time (ms) 0.87 (16) 0.87 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron spike rise time (ms) 1.31 (14) 1.31 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron spike threshold (mV) -51.67 (16) -51.67 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron spike threshold (mV) -54.41 (14) -54.41 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron rheobase (pA) 133.5 (16) 133.5 (pA) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron rheobase (pA) 139.0 (14) 139.0 (pA) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron input resistance 158.3 (16) 158.3 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron input resistance 156.2 (14) 156.2 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron FI slope (Hz/nA) 57.41 (16) 57.41 (Hz/nA) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord segments 4-6 lateral ventral intrinsic alpha motoneuron FI slope (Hz/nA) 71.19 (14) 71.19 (Hz/nA) Data Table