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Article: Chronic spontaneous activity generated in the somata of primary nociceptors is associated with pain-related behavior after spinal cord injury.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Bedi SS; Yang Q; Crook RJ; Du J; Wu Z; Fishman HM; Grill RJ; Carlton SM; Walters ET J. Neurosci., 2010
Table 2.
Electrophysiological properties of small dissociated DRG neurons lacking SA
| Property | Naive | Sham | SCI | SCI vs sham | SCI vs naive | Sham vs naive |
|---|---|---|---|---|---|---|
| Soma diameter (μm) | 23.1 ± 0.4 (22, 106) | 22.8 ± 0.3 (24, 126) | 22.9 ± 0.4 (22, 96) | NS | NS | NS |
| RMP (mV) | −50.9 ± 0.6 (22, 106) | −50.8 ± 0.6 (24, 128) | −52.4 ± 0.6 (23, 96) | NS | NS | NS |
| Rheobase (400 ms pulse, pA) | 64.0 ± 7.1 (22, 94) | 60.2 ± 5.6 (24, 112) | 64.3 ± 6.0 (22, 86) | NS | NS | NS |
| AP threshold at −50 mV (2 ms pulse, pA) | 383 ± 21 (21, 96) | 378 ± 19 (24, 121) | 367 ± 25 (22, 81) | NS | NS | NS |
| AP threshold at −80 mV (2 ms pulse, pA) | 763 ± 27 (21, 95) | 785 ± 25 (24, 122) | 705 ± 32 (22, 81) | NS | p < 0.05 | NS |
| Repetitive firing (spike number, 400 ms) | 2.8 ± 0.2 (22, 102) | 2.8 ± 0.3 (24, 122) | 2.9 ± 0.2 (23, 94) | NS | NS | NS |
| Rm (MΩ) | 534 ± 28 (21, 99) | 541 ± 28 (24, 121) | 592 ± 38 (22, 95) | NS | NS | NS |
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Data are from silent neurons (no SA) sampled from DRGs at all time points and all spinal levels from male and female animals.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Dorsal root ganglion cell | cell diameter (μm) | 23.1 ± 0.4 | 23.1 (um) | Data Table | |
| Dorsal root ganglion cell | resting membrane potential (mV) | -50.9 ± 0.6 | -50.9 (mV) | Data Table | |
| Dorsal root ganglion cell | rheobase | 64.0 ± 7.1 | -- | Data Table | |
| Dorsal root ganglion cell | spike threshold | 383.0 ± 21.0 | -- | Data Table | |
| Dorsal root ganglion cell | spike threshold | 763.0 ± 27.0 | -- | Data Table |