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Article: Electrophysiological and morphological characteristics and synaptic connectivity of tyrosine hydroxylase-expressing neurons in adult mouse striatum.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Ibáñez-Sandoval O; Tecuapetla F; Unal B; Shah F; Koós T; Tepper JM J. Neurosci., 2010
Electrophysiological properties of striatal EGFP–TH+ interneurons in adult mice
| Parameter | Type I (84) | Type II (18) | Type III (8) | Type IV (29) |
|---|---|---|---|---|
| Input resistance (MΩ) | 744 ± 33a,b,c (346 to 1500) | 429 ± 39 (234 to 758) | 180 ± 8f (150 to 205) | 471 ± 30 (235 to 821) |
| n = 78 | n = 17 | n = 8 | n = 29 | |
| Resting membrane potential (mV) | −71 ± 1a,b,c (−50 to −85) | −77 ± 1d (−62 to −82) | −89 ± 1 (−86 to −94) | −74 ± 1f (−55 to −82) |
| n = 79 | n = 18 | n = 8 | n = 29 | |
| AP threshold (mV) | −43 ± 0.3a (−38 to −50) | −47 ± 0.5e (−42 to −50) | −45 ± 0.6 (−42 to −47) | −44 ± 0.5 (−39 to −48) |
| n = 81 | n = 17 | n = 8 | n = 29 | |
| AP width 50% (ms) | 0.78 ± 0.03a,b,c (0.4 to 1.9) | 0.43 ± 0.01 (0.3 to 0.53) | 0.46 ± 0.01 (0.4 to 0.5) | 0.5 ± 0.02 (0.4 to 0.85) |
| n = 81 | n = 17 | n = 8 | n = 29 | |
| AP amplitude (mV) | 76 ± 1.3a (52 to 101) | 94 ± 2d,e (86 to 116) | 79 ± 2 (70 to 88) | 80 ± 1 (63 to 91) |
| n = 81 | n = 17 | n = 8 | n = 29 | |
| AHP amplitude (mV) | 16 ± 0.4a (7 to 24) | 20 ± 0.6d,e (16 to 25) | 14 ± 0.3 (13 to 16) | 15 ± 0.5 (10 to 24) |
| n = 81 | n = 17 | n = 8 | n = 29 | |
| Maximum number of AP (150–200 pA) | 7 ± 0.6a,b,c (2 to 22) | 53 ± 2d,e (45 to 68) | 14 ± 1f (9 to 17) | 28 ± 1 (18 to 45) |
| n = 53 | n = 14 | n = 8 | n = 23 | |
| Maximum frequency (Hz) | 114 ± 9a,c (32 to 256) | 194 ± 10d,e (137 to 265) | 98 ± 6f (66 to 124) | 321 ± 6 (276 to 386) |
| n = 53 | n = 14 | n = 8 | n = 23 | |
| Spontaneous activity | 10 of 84 | 4 of 18 | 0 of 8 | 1 of 29 |
| Plateau potential duration (ms) | 255 ± 31 (46 to 1250) | 150 ± 116 (15 to 381) | 159 ± 41 (119 to 200) | 0 of 26 |
| 39 of 84 | 3 of 12 | 2 of 8 | ||
| LTS component | 0 of 84 | 4 of 18 | 0 of 8 | 29 of 29 |
| Ih ratio | 1.12 ± 0.01 (1.03 to 1.54) | 1.12 ± 0.02 (1.05 to 1.2) | 1.13 ± 0.02 (1.02 to 1.3) | |
| 44 of 84 | 11 of 18 | 0 of 8 | 17 of 29 |
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All values are means ± SEM. Numbers in parentheses refer to the range of values. n refers to number of neurons from which the measurements were obtained. AP, Action potential; AHP, afterhyperpolarization. One-way ANOVA revealed a significant difference effect of type for all parametric measurements. Bonferroni's post hoc comparisons were run to determine specific type to type differences.
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aType I versus Type II; bType I versus Type III; cType I versus Type IV; dType II versus Type III; eType II versus Type IV; fType III versus Type IV.
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a,b,c,d,e,fp < 0.001.
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a,b,c,d,e,fp < 0.05.