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Article: Evidence from computer simulations for alterations in the membrane biophysical properties and dendritic processing of synaptic inputs in mutant superoxide dismutase-1 motoneurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Elbasiouny SM; Amendola J; Durand J; Heckman CJ J. Neurosci., 2010
Experimental data on electrical properties of mSOD1 motoneurons
| Property | WT | mSOD1 |
|---|---|---|
| Input resistance; Rin (MΩ) | 16.2 ± 4.78 (34) | 11.4 ± 2.96*** (23) |
| Resting potential; Vrest (mV) | −70.03 ± 7.16 (34) | −69.61 ± 6.16 (23) |
| Time constant; τ0 (ms) | 11.05 ± 2.64 (11) | 14.4 ± 6.25 (7) |
| Cell capacitance; Ct (pF) | 727 ± 253 (11) | 1404 ± 1055 (7) |
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Experimental data were recorded from neonatal (P8–P10) WT and mSOD1 motoneurons in the whole-cord preparation (2 mm extracellular Ca2+ concentration). Data are expressed as mean ± SD.
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↵***High statistical significance (p = 0.00002 for unpaired t test and 0.00006 for the Mann–Whitney U test). Values in parentheses indicate number of cells in each group. These data include those of the reconstructed motoneurons. Same data as in Figure 1B, right.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Spinal cord ventral horn motor neuron alpha | cell capacitance (pF) | 727.0 ± 253.0 (11) | 727.0 (pF) | Data Table | |
| Spinal cord ventral horn motor neuron alpha | input resistance (MΩ) | 16.2 ± 4.78 (34) | 16.2 (MΩ) | Data Table | |
| Spinal cord ventral horn motor neuron alpha | resting membrane potential (mV) | -70.03 ± 7.16 (34) | -70.03 (mV) | Data Table | |
| Spinal cord ventral horn motor neuron alpha | membrane time constant (ms) | 11.05 ± 2.64 (11) | -- | Data Table |