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Article: Distinct roles of GABAergic interneurons in the regulation of striatal output pathways.

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Gittis AH; Nelson AB; Thwin MT; Palop JJ; Kreitzer AC
J. Neurosci., 2010


Table 1.

Intrinsic properties of striatal neurons: summary of cell parameters collected from GFP-positive PLTS and FS interneurons as well as GFP-negative MSNs and cholinergic interneurons

PLTS FS MSN Cholinergic
N 32 22 11 9
AP half-width (ms)* 1.3 ± 0.3 0.5 ± 0.1 1.5 ± 0.2 2.1 ± 0.2
MaxFR (Hz)* 29 ± 34 287 ± 88 69 ± 11 60 ± 18
V rest (mV)* −61 ± 10 −82 ± 5 −92 ± 4 −57 ± 4
Plateau potential (mV)* 6.4 ± 5.2 −1.7 ± 2.4 0.7 ± 0.7 −6.1 ± 6.7
Holding current at −70 mV (pA) † −14 ± 15 67 ± 37 207 ± 25 −99 ± 60
Input resistance (MΩ) † 830 ± 525 198 ± 126 142 ± 60 229 ± 69
Capacitance (pF) † 65 ± 8 98 ± 24 118 ± 22 98 ± 12

  • Each cell type is easily distinguished using various combinations of these parameters.

  • ↵*Parameters measured in current clamp;

  • ↵ †parameters measured in voltage clamp.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum cholinergic cell spike half-width (ms) 2.1 ± 0.2 (9) 2.1 (ms) Data Table
Neostriatum gabaergic interneuron Dorsal striatum persistent low-threshold spiking neuropeptide Y, somatostasin and nitric oxide synthase expressing GABAergic interneuron maximum firing rate (Hz) 29.0 ± 34.0 (32) 29.0 (Hz) Data Table
Neostriatum gabaergic interneuron Dorsal striatum fast-spiking parvalbumin-expressing GABAergic interneuron maximum firing rate (Hz) 287.0 ± 88.0 (22) 287.0 (Hz) Data Table
Neostriatum medium spiny neuron maximum firing rate (Hz) 69.0 ± 11.0 (11) 69.0 (Hz) Data Table
Neostriatum cholinergic cell maximum firing rate (Hz) 60.0 ± 18.0 (9) 60.0 (Hz) Data Table
Neostriatum gabaergic interneuron Dorsal striatum persistent low-threshold spiking neuropeptide Y, somatostasin and nitric oxide synthase expressing GABAergic interneuron resting membrane potential (mV) -61.0 ± 10.0 (32) -61.0 (mV) Data Table
Neostriatum gabaergic interneuron Dorsal striatum fast-spiking parvalbumin-expressing GABAergic interneuron resting membrane potential (mV) -82.0 ± 5.0 (22) -82.0 (mV) Data Table
Neostriatum medium spiny neuron resting membrane potential (mV) -92.0 ± 4.0 (11) -92.0 (mV) Data Table
Neostriatum cholinergic cell resting membrane potential (mV) -57.0 ± 4.0 (9) -57.0 (mV) Data Table
Neostriatum gabaergic interneuron Dorsal striatum persistent low-threshold spiking neuropeptide Y, somatostasin and nitric oxide synthase expressing GABAergic interneuron input resistance (MΩ) 830.0 ± 525.0 (32) 830.0 (MΩ) Data Table
Neostriatum gabaergic interneuron Dorsal striatum fast-spiking parvalbumin-expressing GABAergic interneuron input resistance (MΩ) 198.0 ± 126.0 (22) 198.0 (MΩ) Data Table
Neostriatum medium spiny neuron input resistance (MΩ) 142.0 ± 60.0 (11) 142.0 (MΩ) Data Table
Neostriatum cholinergic cell input resistance (MΩ) 229.0 ± 69.0 (9) 229.0 (MΩ) Data Table
Neostriatum gabaergic interneuron Dorsal striatum persistent low-threshold spiking neuropeptide Y, somatostasin and nitric oxide synthase expressing GABAergic interneuron cell capacitance (pF) 65.0 ± 8.0 (32) 65.0 (pF) Data Table
Neostriatum gabaergic interneuron Dorsal striatum fast-spiking parvalbumin-expressing GABAergic interneuron cell capacitance (pF) 98.0 ± 24.0 (22) 98.0 (pF) Data Table
Neostriatum medium spiny neuron cell capacitance (pF) 118.0 ± 22.0 (11) 118.0 (pF) Data Table
Neostriatum cholinergic cell cell capacitance (pF) 98.0 ± 12.0 (9) 98.0 (pF) Data Table
Neostriatum gabaergic interneuron Dorsal striatum persistent low-threshold spiking neuropeptide Y, somatostasin and nitric oxide synthase expressing GABAergic interneuron spike half-width (ms) 1.3 ± 0.3 (32) 1.3 (ms) Data Table
Neostriatum gabaergic interneuron Dorsal striatum fast-spiking parvalbumin-expressing GABAergic interneuron spike half-width (ms) 0.5 ± 0.1 (22) 0.5 (ms) Data Table
Neostriatum medium spiny neuron spike half-width (ms) 1.5 ± 0.2 (11) 1.5 (ms) Data Table