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Article: Similar neurons, opposite adaptations: psychostimulant experience differentially alters firing properties in accumbens core versus shell.

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Kourrich S; Thomas MJ
J. Neurosci., 2009


Table 1.

Repeated in vivo cocaine altered membrane properties of NAc shell and core neurons

Early abstinence (1–3 d) Late abstinence (10–14 d)
Shell Core Shell Core
SAL COC SAL COC SAL COC SAL COC
Passive membrane properties
    RMP (mV) −80.5 ± 0.4 −80.7 ± 0.5 −78.6 ± 0.50 −79.0 ± 0.5 −78.8 ± 0.5 −78.5 ± 0.4 −79.4 ± 0.8 −78.3 ± 0.8
    Ri (MΩ) 180.2 ± 10.1 174.1 ± 8.5 141.6 ± 6.8 135.6 ± 8.8 174.8 ± 8.4 188.0 ± 7.1 151.9 ± 11.6 165.4 ± 8.6
Active membrane properties
    Rheobase (current togenerate a spike, pA) 124 ± 5.8 139.4 ± 7.6 137.5 ± 10.0 116.2 ± 4.4 130.0 ± 9.7 135.5 ± 7.8 132.7 ± 11.8 134 ± 8.8
    Spike threshold (mV) −35.3 ± 0.8 −33.7 ± 0.8 −33.2 ± 0.5 −35.2 ± 0.6* −35.2 ± 0.8 −32.6 ± 0.6** −34.9 ± 0.7 −34.4 ± 0.9
    Spike amplitude (mV) 69.4 ± 2.2 69.7 ± 1.5 77.1 ± 1.0 83.8 ± 1.8** 76.8 ± 1.6 72.0 ± 1.4* 78.3 ± 1.6 79.6 ± 2.2
    Spike duration (ms) 2.60 ± 0.06 2.69 ± 0.06 2.57 ± 0.06 2.45 ± 0.04 2.39 ± 0.03 2.57 ± 0.04*** 2.56 ± 0.06 2.62 ± 0.06
    AHP amplitude (mV) 15.2 ± 0.6 14.2 ± 0.4 15.3 ± 0.4 15.6 ± 0.4 15.0 ± 0.2 15.8 ± 0.4 16.7 ± 0.6 15.2 ± 0.4
    Spike rise (10%–90%, ms) 0.76 ± 0.04 0.82 ± 0.04 0.72 ± 0.04 0.60 ± 0.02* 0.62 ± 0.03 0.74 ± 0.03*** 0.69 ± 0.04 0.69 ± 0.04

  • ↵Values represent the mean± SEM (*p < 0.05; **p < 0.01; ***p < 0.001; with two-tailed Student's t test used to compare with their respective saline control group). The RMP and the spike threshold were not adjusted for the liquid junction potential (∼8 mV). Spike characteristics were obtained from the first spike evoked by the minimal depolarizing current pulse in every NAc neuron recorded; the spike threshold was obtained by using the maximum of the third differential during the rising phase. The other characteristics were measured as follows: spike amplitude, difference between spike threshold and peak; spike duration, measured at 20 pA above threshold; AHP amplitude, difference between spike threshold and maximum hyperpolarization after the spike; spike rise, time difference between 10 and 90% of the spike peak.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus accumbens shell neuron resting membrane potential (mV) -80.5 ± 0.4 (10) -80.5 (mV) Data Table
Nucleus accumbens core neuron resting membrane potential (mV) -78.6 ± 0.5 (16) -78.6 (mV) Data Table
Nucleus accumbens shell neuron input resistance (MΩ) 180.2 ± 10.1 (10) 180.2 (MΩ) Data Table
Nucleus accumbens core neuron input resistance (MΩ) 141.6 ± 6.8 (16) 141.6 (MΩ) Data Table
Nucleus accumbens shell neuron rheobase 124.0 ± 5.8 (10) 124.0 (pA) Data Table
Nucleus accumbens core neuron rheobase 137.5 ± 10.0 (16) 137.5 (pA) Data Table
Nucleus accumbens shell neuron spike threshold (mV) -35.3 ± 0.8 (10) -35.3 (mV) Data Table
Nucleus accumbens core neuron spike threshold (mV) -33.2 ± 0.5 (16) -33.2 (mV) Data Table
Nucleus accumbens shell neuron spike amplitude (mV) 69.4 ± 2.2 (10) 69.4 (mV) Data Table
Nucleus accumbens core neuron spike amplitude (mV) 77.1 ± 1.0 (16) 77.1 (mV) Data Table
Nucleus accumbens shell neuron spike width (ms) 2.6 ± 0.06 (10) 2.6 (ms) Data Table
Nucleus accumbens core neuron spike width (ms) 2.57 ± 0.06 (16) 2.57 (ms) Data Table
Nucleus accumbens shell neuron AHP amplitude (mV) 15.2 ± 0.6 (10) 15.2 (mV) Data Table
Nucleus accumbens core neuron AHP amplitude (mV) 15.3 ± 0.4 (16) 15.3 (mV) Data Table
Nucleus accumbens shell neuron spike rise time 0.76 ± 0.04 (10) 0.76 (ms) Data Table
Nucleus accumbens core neuron spike rise time 0.72 ± 0.04 (16) 0.72 (ms) Data Table