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Article: Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Benavides DR; Quinn JJ; Zhong P; Hawasli AH; DiLeone RJ; Kansy JW; Olausson P; Yan Z; Taylor JR; Bibb JA J. Neurosci., 2007
Table 1.
Membrane properties of NAc medium spiny neurons from control and Cdk5 cKO mice
| Control | Cdk5 cKO | |
|---|---|---|
| Resting membrane potential (mV) | −81.8 ± 2.2 | −78.7 ± 1.0 |
| Rheobase (pA) | 158.3 ± 4.2 | 137.6 ± 5.3* |
| Latency to first spike (ms) | 312.8 ± 45.3 | 155.0 ± 20.5* |
| Spike threshold (mV) | −42.8 ± 0.7 | −41.2 ± 1.2 |
| Spike amplitude (mV) | 72.4 ± 3.4 | 70.3 ± 2.5 |
| Spike half-width (ms) | 1.4 ± 0.2 | 1.5 ± 0.3 |
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Rheobase value was determined as the smallest current injection that elicited a single spike. Latency to first spike was measured from 180 pA current injection. Values are expressed as mean ± SEM. *p < 0.05, Student's t test, n = 7–8 per group.