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Article: Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence seizures.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Polack PO; Guillemain I; Hu E; Deransart C; Depaulis A; Charpier S J. Neurosci., 2007
Intrinsic membrane properties of neurons recorded from GAERS and normal Wistar rats
| Membrane resistance (MΩ) | Time constant (ms) | Action potential amplitude (mV) | Action potential duration (ms) | Action potential threshold (mV) | ||
|---|---|---|---|---|---|---|
| GAERS | ||||||
| Focus | Layer 2/3 | 27.5 ± 3.7 | 9.9 ± 2.5 | 56.5 ± 2.9 | 1.7 ± 0.1 | −50.6 ± 1.3 |
| Layer 4 | 43.4 ± 3.2 1 | 14.2 ± 2.0 | 53.8 ± 4.9 | 1.8 ± 0.1 | −52.0 ± 2.8 | |
| Layer 5/6 | 21.7 ± 2.2 1 | 7.9 ± 0.9 | 57.8 ± 2.3 | 1.6 ± 0.1 | −53.6 ± 0.6 | |
| MoCx | Layer 5/6 | 25.8 ± 3.6 1 | 14.0 ± 2.5 | 60.4 ± 1.8 | 1.6 ± 0.1 | −53.2 ± 0.9 |
| Wistar | ||||||
| SoCx | Layer 5/6 | 30.0 ± 4.1 | 6.5 ± 0.9 | 56.7 ± 1.1 | 1.8 ± 0.2 | −52.8 ± 1.2 |
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Electrical parameters were measured in GAERS neurons, located in layer 2/3 (n = 6), layer 4 (n = 5), and layer 5/6 (n = 17) of the cortical focus and in layer 5/6 of motor cortex (MoCx; n = 9) and in nonepileptic Wistar rat somatosensory cortical neurons (SoCx; n = 7). All parameters were not significantly different (p > 0.05), except the membrane resistance of GAERS focus layer 4 neurons that was significantly higher than that of focus and motor cortex layer 5/6 cells (p < 0.001).
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neocortex pyramidal cell layer 5-6 | somatosensory cortex layer 5/6 pyramidal neurons | input resistance (MΩ) | 30.0 ± 4.1 (7) | 30.0 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 5-6 | somatosensory cortex layer 5/6 pyramidal neurons | membrane time constant (ms) | 6.5 ± 0.9 (7) | 6.5 (ms) | Data Table |
| Neocortex pyramidal cell layer 5-6 | somatosensory cortex layer 5/6 pyramidal neurons | spike amplitude (mV) | 56.7 ± 1.1 (7) | 56.7 (mV) | Data Table |
| Neocortex pyramidal cell layer 5-6 | somatosensory cortex layer 5/6 pyramidal neurons | spike width (ms) | 1.8 ± 0.2 (7) | 1.8 (ms) | Data Table |
| Neocortex pyramidal cell layer 5-6 | somatosensory cortex layer 5/6 pyramidal neurons | spike threshold (mV) | -52.8 ± 1.2 (7) | -52.8 (mV) | Data Table |