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Article: Background synaptic activity is sparse in neocortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Waters J; Helmchen F
J. Neurosci., 2006


Table 1.

Electrophysiological properties of neocortical L2/3 neurons in vivo

Pyramidal cell somatic recording (n = 16) Pyramidal cell dendritic recordinga (n = 3) FS interneuron (n = 2) Pyramidal cell microelectrode recording (n = 3) Pyramidal cell with QX-314 (n = 4)
Resting Vm, Down (mV) −73.9 ± 1.4 −78.7 ± 2.2 −76.1 ± 6.4 −75.3 ± 3.4 −63.1 ± 3.3
Resting Vm, Up (mV) −58.9 ± 1.2 −66.2 ± 1.2 −56.8 ± 5.2 −61.2 ± 4.8 −47.9 ± 2.7
ΔV (Up–Down) (mV) 15.0 ± 0.9 12.6 ± 1.8 19.4 ± 1.2 14.1 ± 2.1 15.1 ± 3.4
Vm SD, Up (mV) 2.5 ± 0.1 3.2 ± 0.4 3.4 ± 0.3 3.2 ± 0.3
Mean dwell time, Down (ms) 347 ± 32 343 ± 24 (n = 4)
Mean dwell time, Up (ms) 457 ± 57 224 ± 26 (n = 4)
AP threshold (mV) −36.4 ± 1.0 −44.3 ± 2.7 −34.1 ± 6.6 −41.7 ± 3.2
AP amplitudeb (mV) 66.5 ± 3.4 51.7 ± 8.2 32.2 ± 8.2 72.3 ± 3.2
AP half-width (ms) 0.84 ± 0.06 0.89 ± 0.08 0.34 ± 0.05 0.66 ± 0.01
RN Down (MΩ) 29.2 ± 2.0 25.7 ± 0.6 53.5 ± 3.1 22.5 ± 3.5 52.7 ± 4.8
RN Discards (MΩ) 31.6 ± 2.2 32.4 ± 3.7 54.0 ± 0.2 24.5 ± 6.8 56.3 ± 4.5
RN Up (MΩ) 36.6 ± 2.3 28.2 ± 1.3 57.3 ± 3.4 23.6 ± 4.4 44.6 ± 2.2
τdecay Downc (ms) 9.0 ± 0.6 8.5 ± 0.8 2.6 ± 0.9 8.9 ± 1.1 20.1 ± 1.2
τdecay Discardsc (ms) 10.6 ± 0.6 6.9 ± 2.5 2.7 ± 0.9 9.3 ± 2.7 21.6 ± 1.7
τdecay Upc (ms) 12.8 ± 1.1 16.5 ± 5.3 2.7 ± 0.9 9.9 ± 2.1 16.3 ± 3.8
Anomalous rectification, cAR (MΩ/nA) 18.7 ± 3.7 (n = 10) 0.6 ± 6.4 (n = 6)
RN Down, from V–I curve (MΩ) 27.5 ± 2.1 (n = 10) 68.1 ± 4.8 (n = 6)
RN Up, from V–I curve (MΩ) 44.1 ± 4.0 (n = 10)

  • All data are given as mean ± SE.

  • ↵aA total of 60–100 μm from the soma.

  • ↵bFrom threshold.

  • ↵cTime constant of off-response (starting 1 ms after end of current pulse).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 resting membrane potential (mV) -73.9 ± 1.4 (16) -73.9 (mV) Data Table
Neocortex pyramidal cell layer 2-3 spike threshold (mV) -36.4 ± 1.0 (16) -36.4 (mV) Data Table
Neocortex basket cell resting membrane potential (mV) -76.1 ± 6.4 (2) -76.1 (mV) Data Table
Neocortex basket cell spike threshold (mV) -34.1 ± 6.6 (2) -34.1 (mV) Data Table
Neocortex pyramidal cell layer 2-3 spike amplitude (mV) 66.5 ± 3.4 (16) 66.5 (mV) Data Table
Neocortex basket cell spike amplitude (mV) 32.2 ± 8.2 (2) 32.2 (mV) Data Table
Neocortex pyramidal cell layer 2-3 spike half-width (ms) 0.84 ± 0.06 (16) 0.84 (ms) Data Table
Neocortex basket cell spike half-width (ms) 0.34 ± 0.05 (2) 0.34 (ms) Data Table
Neocortex pyramidal cell layer 2-3 input resistance (MΩ) 29.2 ± 2.0 (16) 29.2 (MΩ) Data Table
Neocortex basket cell input resistance (MΩ) 53.5 ± 3.1 (2) 53.5 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 membrane time constant (ms) 9.0 ± 0.6 (16) 9.0 (ms) Data Table
Neocortex basket cell membrane time constant (ms) 2.6 ± 0.9 (2) 2.6 (ms) Data Table