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Article: Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Kumar SS; Buckmaster PS J. Neurosci., 2006
Intrinsic electrophysiological properties of interneurons and pyramidal cells in layer III of the medial entorhinal cortex in control and epileptic rats
| Type I interneuron | Type II interneuron | Layer III pyramidal cell | Significant differences | |
|---|---|---|---|---|
| Resting membrane potential (mV) | −64 ± 1.3 | −54 ± 1.1 | −55 ± 1.5 | II = Pyr > I |
| (n = 28) | (n = 25) | (n = 9) | ||
| Membrane resistance (MΩ) | 143 ± 11 | 382 ± 47 | 49 ± 3 | II > I = Pyr |
| (n = 28) | (n = 25) | (n = 5) | ||
| Membrane capacitance (pF) | 51 ± 3 | 51 ± 1 | 130 ± 9 | Pyr > I = II |
| (n = 28) | (n = 25) | (n = 5) | ||
| Action potential half-width (ms) | 0.2 ± 0.01 | 0.4 ± 0.01 | 0.5 ± 0.04 | Pyr = II > I |
| (n = 11) | (n = 11) | (n = 9) | ||
| Spike afterhyperpolarization amplitude (mV) | 31 ± 1.3 | 38 ± 1.5 | 7 ± 0.4 | II > I > Pyr |
| (n = 11) | (n = 11) | (n = 9) |
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Values are mean ± SEM. ANOVA revealed significant differences between neuron types for every property (p < 0.0001). Post hoc Bonferroni's-adjusted t test showed significant differences (p < 0.05) as indicated between type I interneurons (I), type II interneurons (II), and layer III pyramidal cells (Pyr). > indicates significant difference; = indicates no significant difference.