TABLE 1.
Effects of 100 nM α-DTX on membrane properties and action potential characteristics of Mes V neurons
AP amp, mV | AHP amp, mV | AP width, ms | AP thres, mV | RMP, mV | Rinp, MΩ | Rheobase, pA | |
---|---|---|---|---|---|---|---|
Control | 108.3 ± 4.7 | 15.1 ± 1.5 | 0.75 ± 0.07 | −46.6 ± 2.4 | −61.8 ± 1.5 | 101.0 ± 18.4 | 400.3 ± 29.0 |
α-DTX | 109.2 ± 4.2 | 10.5 ± 1.7 | 0.84 ± 0.06 | −48.5 ± 2.3 | −60.0 ± 1.9 | 151.2 ± 41.3 | 355.5 ± 25.8 |
Total cells | 9 | 9 | 9 | 9 | 9 | 9 | 9 |
P value | NS | 0.01 | NS | 0.02 | 0.02 | 0.015 | 0.0006 |
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Values are means ± SE. α-DTX, α-dendrotoxin; Mes V, mesencephalic V; NS, not significant.