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Article: Corticotropin-releasing hormone directly activates noradrenergic neurons of the locus ceruleus recorded in vitro.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Jedema HP; Grace AA J. Neurosci., 2004
Table 1.
Action potential characteristics
| Control | CRH | |
|---|---|---|
| Threshold (in millivolts) | −45.9 ± 2.1 | −45.7 ± 2.1 |
| Amplitude (in millivolts) | 71.7 ± 1.2 | 71.3 ± 1.2 |
| Duration (in milliseconds) | 2.0 ± 0.1 | 2.0 ± 0.1 |
| AHP (in millivolts) | 20.4 ± 0.5 | 20.3 ± 0.6 |
| Interspike interval (in milliseconds) | 585 ± 114 | a421 ± 84 |
| Rate of repolarization (in millivolts per second) | 55 ± 7 | a74 ± 9 |
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Data show the characteristics of spontaneously occurring action potentials recorded during a 5 sec epoch of maximal CRH-evoked activation compared with the same number of action potentials recorded immediately before CRH administration (2 pulses for each neuron) in 10 LC neurons.
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↵ a p < 0.05.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Locus coeruleus noradrenergic neuron | AHP amplitude | 20.4 ± 0.5 (4) | 20.4 (mV) | Data Table | |
| Locus coeruleus noradrenergic neuron | spike max decay slope | 55.0 ± 7.0 (4) | 55.0 (mV/ms) | Data Table | |
| Locus coeruleus noradrenergic neuron | spike threshold | -45.9 ± 2.1 (4) | -45.9 (mV) | Data Table | |
| Locus coeruleus noradrenergic neuron | spike amplitude | 71.7 ± 1.2 (4) | 71.7 (mV) | Data Table | |
| Locus coeruleus noradrenergic neuron | spike width | 2.0 ± 0.1 (4) | 2.0 (ms) | Data Table |