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Article: Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Stern EA; Bacskai BJ; Hickey GA; Attenello FJ; Lombardo JA; Hyman BT J. Neurosci., 2004
Table 1.
Intrinsic and spontaneous membrane potential properties of mouse cortical neurons recorded in vivo
| Tg− | Tg+ | |||
|---|---|---|---|---|
| Measurement | 8-10 months | ≥14 months | 8-10 months | ≥14 months |
| Down state | ||||
| Membrane potential (mV) | −63.2 ± 4.6 (n = 8) | −61.8 ± 4.2 (n = 10) | −62.4 ± 3.8 (n = 8) | −63.5 ± 4.8 (n = 11) |
| Duration (msec) | 652.4 ± 237.6 (n = 8) | 769.0 ± 236.3 (n = 10) | 721.7 ± 311.4 (n = 8) | 684.8 ± 276.2 (n = 11) |
| Up state | ||||
| Membrane potential (mV) | −52.8 ± 6.2 (n = 8) | −51.5 ± 4.9 (n = 8) | −53.1 ± 5.7 (n = 8) | −54.1 ± 5.2 (n = 8) |
| Duration (msec) | 424.0 ± 280.5 (n = 8) | 467.4 ± 322.1 (n = 10) | 390.8 ± 316.2 (n = 8) | 406.9 ± 388.5 (n = 11) |
| Spontaneous firing rate (Hz) | 14.0 ± 6.7 (n = 8) | 12.8 ± 6.0 (n = 10) | 11.6 ± 8.5 (n = 8) | 16 ± 9.3 (n = 11) |
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neocortex uncharacterized cell | Neocortex Pyramidal Neuron | spontaneous firing rate (Hz) | 14.0 ± 6.7 (8) | 14.0 (Hz) | Data Table |
| Neocortex uncharacterized cell | Neocortex Pyramidal Neuron | spontaneous firing rate (Hz) | 12.8 ± 6.0 (10) | 12.8 (Hz) | Data Table |
| Neocortex uncharacterized cell | Neocortex Pyramidal Neuron | resting membrane potential (mV) | -63.2 ± 4.6 (8) | -63.2 (mV) | Data Table |
| Neocortex uncharacterized cell | Neocortex Pyramidal Neuron | resting membrane potential (mV) | -61.8 ± 4.2 (10) | -61.8 (mV) | Data Table |