AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Age-dependent effect of hearing loss on cortical inhibitory synapse function.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Takesian AE; Kotak VC; Sanes DH
J. Neurophysiol., 2012


Table 1.

Effects of early CHL on adult FS and LTS cell intrinsic properties

FS control FS CHL LTS Control LTS CHL
n 10 7 13 20
RMP,mV −59 ± 2 −57 ± 1 −59 ± 2 −59 ± 1
Rin, MΩ 142 ± 20 211 ± 69 151 ± 10 175 ± 19
τ, ms 4.8 ± 0.5 5.2 ± 1.2 9.7 ± 1.3 10.3 ± 1.1
I thresh, pA 123 ± 22 206 ± 76 105 ± 15 93 ± 16
V thresh, mV −40 ± 2 −35 ± 2 −43 ± 2 −43 ± 2
AP width, ms 0.30 ± 0.02 0.34 ± 0.04 0.74 ± 0.03 0.81 ± 0.04
AHP, mv −19 ± 1 −19 ± 1 −14 ± 1 −14 ± 1
AP amp, mV 87 ± 5 98 ± 2 104 ± 2 107 ± 2
Adaptation ratio 1.4 ± 0.2 3.6 ± 0.7† 5.3 ± 1.1 8.1 ± 2.2
Max spike rate, Hz 235 ± 23 141 ± 20* 49 ± 10 47 ± 5

  • Values are means ± SE (n = no. of cells sampled) of intrinsic properties of fast-spiking (FS) and low-threshold-spiking (LTS) interneurons from adult [postnatal day (P)180–P200] control and conductive hearing loss (CHL) animals.

  • ↵* P < 0.05;

  • ↵† P < 0.01. RMP, resting membrane potential; Rin, input resistance; τ, membrane time constant; I thresh, current threshold required to elicit a spike; V thresh, voltage threshold to spike; AP width, action potential half-width; AP amp, action potential amplitude; adaptation ratio, average of last 2 interspike-intervals (ISI) divided by average of first 2 ISIs; Max spike rate, maximum spike rate evoked by ≤800-pA current injection.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell Auditory cortex fast-spiking cell input resistance (MΩ) 142.0 ± 20.0 (10) 142.0 (MΩ) Data Table
Neocortex Martinotti cell Auditory cortex low-threshold spiking cell input resistance (MΩ) 151.0 ± 10.0 (13) 151.0 (MΩ) Data Table
Neocortex basket cell Auditory cortex fast-spiking cell membrane time constant (ms) 4.8 ± 0.5 (10) 4.8 (ms) Data Table
Neocortex Martinotti cell Auditory cortex low-threshold spiking cell membrane time constant (ms) 9.7 ± 1.3 (13) 9.7 (ms) Data Table
Neocortex basket cell Auditory cortex fast-spiking cell rheobase (pA) 123.0 ± 22.0 (10) 123.0 (pA) Data Table
Neocortex Martinotti cell Auditory cortex low-threshold spiking cell rheobase (pA) 105.0 ± 15.0 (13) 105.0 (pA) Data Table
Neocortex basket cell Auditory cortex fast-spiking cell spike threshold (mV) -40.0 ± 2.0 (10) -40.0 (mV) Data Table
Neocortex Martinotti cell Auditory cortex low-threshold spiking cell spike threshold (mV) -43.0 ± 2.0 (13) -43.0 (mV) Data Table
Neocortex basket cell Auditory cortex fast-spiking cell spike half-width (ms) 0.3 ± 0.02 (10) 0.3 (ms) Data Table
Neocortex Martinotti cell Auditory cortex low-threshold spiking cell spike half-width (ms) 0.74 ± 0.03 (13) 0.74 (ms) Data Table
Neocortex basket cell Auditory cortex fast-spiking cell AHP amplitude -19.0 ± 1.0 (10) 19.0 (mV) Data Table
Neocortex Martinotti cell Auditory cortex low-threshold spiking cell AHP amplitude -14.0 ± 1.0 (13) 14.0 (mV) Data Table
Neocortex basket cell Auditory cortex fast-spiking cell spike amplitude (mV) 87.0 ± 5.0 (10) 87.0 (mV) Data Table
Neocortex Martinotti cell Auditory cortex low-threshold spiking cell spike amplitude (mV) 104.0 ± 2.0 (13) 104.0 (mV) Data Table
Neocortex basket cell Auditory cortex fast-spiking cell adaptation ratio (last/first ISI) 1.4 ± 0.2 (10) 1.4 (ratio) Data Table
Neocortex Martinotti cell Auditory cortex low-threshold spiking cell adaptation ratio (last/first ISI) 5.3 ± 1.1 (13) 5.3 (ratio) Data Table
Neocortex basket cell Auditory cortex fast-spiking cell maximum firing rate (Hz) 235.0 ± 23.0 (10) 235.0 (Hz) Data Table
Neocortex Martinotti cell Auditory cortex low-threshold spiking cell maximum firing rate (Hz) 49.0 ± 10.0 (13) 49.0 (Hz) Data Table
Neocortex basket cell Auditory cortex fast-spiking cell resting membrane potential (mV) -59.0 ± 2.0 (10) -59.0 (mV) Data Table
Neocortex Martinotti cell Auditory cortex low-threshold spiking cell resting membrane potential (mV) -59.0 ± 2.0 (13) -59.0 (mV) Data Table