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Article: Dopamine modulates excitability of spiny neurons in the avian basal ganglia.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Ding L; Perkel DJ J. Neurosci., 2002
Table 1.
Measurements of intrinsic properties of spiny neurons before and during drug application
| PRE | DA (n = 15) | PRE | QUIN (n = 16) | PRE | SKF (n = 14) | |
|---|---|---|---|---|---|---|
| V m(mV) | −81.6 ± 5.64 | −81.3 ± 5.98 | −77.8 ± 10.2 | −77.4 ± 10.2 | −76.4 ± 7.95 | −75.9 ± 8.22 |
| Initial ramp slope (mV/sec) | 75.1 ± 32.0 | 69.3 ± 33.5 | 77.2 ± 37.2 | 57.6 ± 37.8 | 61.8 ± 21.0 | 65.2 ± 20.6 |
| Spike amplitude (mV) | 39.9 ± 9.52 | 37.2 ± 9.19 | 35.9 ± 9.50 | 33.0 ± 11.2 | 40.4 ± 10.8 | 37.4 ± 10.4 |
| Spike threshold (mV) | −34.3 ± 5.95 | −32.8 ± 6.24 | −37.7 ± 7.23 | −37.7 ± 8.68 | −38.9 ± 5.76 | −37.4 ± 7.21 |
| Latency to first spike (msec) | 208 ± 68.0 | 234 ± 103 | 175 ± 73.4 | 257 ± 108 | 207 ± 125 | 185 ± 99.3 |
| AHP amplitude (mV) | −12.6 ± 4.34 | −12.4 ± 4.58 | −11.7 ± 4.20 | −11.6 ± 4.81 | −8.15 ± 7.69 | −7.40 ± 6.01 |
| AHP duration (msec) | 15.9 ± 5.18 | 16.6 ± 5.71 | 22.0 ± 11.9 | 24.6 ± 16.0 | 18.6 ± 11.8 | 18.8 ± 12.0 |
| R input (MΩ) | 233 ± 130 | 240 ± 126 | 267 ± 165 | 246 ± 142 | 246 ± 103 | 254 ± 112 |
| Inward rectification ratio | 0.69 ± 0.08 | 0.72 ± 0.10 | 0.70 ± 0.12 | 0.73 ± 0.11 | 0.68 ± 0.12 | 0.69 ± 0.08 |
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Each measurement is expressed as mean ± SD. PRE, Control; QUIN, quinpirole application; SKF, SKF-38393 application. Bold type indicates p < 0.05; two-tailed Wilcoxon signed rank test.