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Article: Long-term IL-1β exposure causes subpopulation-dependent alterations in rat dorsal root ganglion neuron excitability.

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Stemkowski PL; Smith PA
J. Neurophysiol., 2012


Table 1.

Summary of AP parameters and passive membrane properties in control versus IL-1β-treated DRG neurons

Parameter Large Neuron Control Large Neuron IL-1β Medium Neuron Control Medium Neuron IL-1β Small IB4+ Neuron Control Small IB4+ Neuron IL-1β Small IB4− Neuron Control Small IB4− Neuron IL-1β
RMP, mV −54.3 ± 1.9 (12) −57.9 ± 1.0 (10) −61.4 ± 0.8 (36) −59.5 ± 1.0 (38) −58.5 ± 1.4 (20) −57.0 ± 1.9 (21) −57.0 ± 1.4 (23) −57.3 ± 1.5 (24)
AP threshold, mV −27.4 ± 4.5 (10) −31.3 ± 1.6 (10) −23.3 ± 2.4 (31) −27.3 ± 1.3 (37) −24.1 ± 1.9 (18) −17.6 ± 3.3 (18) −25.6 ± 1.8 (17) −20.3 ± 2.0 (23)
Spike height, mV 101.3 ± 6.5 (12) 115.3 ± 4.0 (10) 97.3 ± 2.5 (36) 106.6 ± 2.3 (38)† 103.8 ± 3.4 (20) 95.6 ± 4.9 (21) 104.6 ± 4.0 (23) 107.6 ± 3.2 (24)
Spike width, ms 2.00 ± 0.39 (12) 2.59 ± 0.42 (10) 2.05 ± 0.15 (36) 2.24 ± 0.29 (38) 1.86 ± 0.12 (20) 2.52 ± 0.16 (21)† 3.29 ± 0.43 (23) 3.39 ± 0.29 (24)
Maximal rate of AP depolarization, mV/ms 124.5 ± 17.2 (12) 146.9 ± 11.4 (10) 95.5 ± 5.8 (36) 124.6 ± 6.1 (38)‡ 110.0 ± 7.4 (20) 84.9 ± 10.0 (21) 107.9 ± 9.7 (23) 122.2 ± 7.3 (24)
Maximal rate of AP repolarization, mV/ms −68.2 ± 8.8 (12) −52.1 ± 5.1 (10) −52.1 ± 2.5 (36) −66.8 ± 4.1 (38)† −57.9 ± 3.3 (20) −46.6 ± 2.9 (21)* −49.0 ± 4.5 (23) −43.9 ± 2.3 (24)
AHP amplitude, mV −16.9 ± 1.8 (12) −13.1 ± 0.8 (10) −17.7 ± 0.8 (36) −14.2 ± 1.0 (38)† −20.1 ± 0.9 (20) −18.3 ± 1.0 (21) −15.4 ± 1.4 (23) −13.9 ± 1.8 (24)
AHP duration at 25% repolarization, ms 11.45 ± 1.90 (11) 35.26 ± 6.71 (9)† 15.88 ± 0.92 (36) 15.72 ± 1.89 (38) 17.75 ± 2.00 (20) 14.50 ± 1.70 (21) 13.89 ± 1.5 (23) 17.92 ± 1.95 (20)
AHP duration at 50% repolarization, ms 25.42 ± 4.62 (11) 26.93 ± 9.49 (3)§ 34.99 ± 2.15 (36) 26.68 ± 1.93(33)† 35.2 6 ± 3.65 (18) 30.26 ± 3.39 (19) 30.06 ± 3.01 (19) 33.31 ± 3.78 (16)
Rheobase, nA 0.39 ± 0.05 (12) 0.54 ± 0.04* (10) 0.49 ± 0.03 (36) 0.41 ± 0.02 (38)* 0.37 ± 0.03 (20) 0.33 ± 0.02 (21) 0.27 ± 0.02 (23) 0.24 ± 0.02 (24)
Input resistance, MΩ 192 ± 30 (12) 190 ± 37 (10) 330 ± 23 (36) 297 ± 23 (38) 453 ± 35 (20) 490 ± 55 (21) 603 ± 50 (23) 679 ± 46 (22)

  • Values are means ± SE (n in parentheses). AP, action potential; DRG, dorsal root ganglion; IB4, isolectin B4; RMP, resting membrane potential; AHP, afterhyperpolarization. Statistical significance determined with unpaired t-test or Fisher's exact test. Significant difference vs. control:

  • ↵* P < 0.05,

  • ↵† P < 0.01,

  • ↵‡ P < 0.001 with unpaired t-test;

  • ↵§ P < 0.01 with Fisher's exact test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell Large dorsal root ganglion cell spike threshold (mV) -27.4 ± 4.5 (10) -27.4 (mV) Data Table
Dorsal root ganglion cell Medium dorsal root ganglion cell spike threshold (mV) -23.3 ± 2.4 (31) -23.3 (mV) Data Table
Dorsal root ganglion cell Small isolectin B4 positive dorsal root ganglion cell spike threshold (mV) -24.1 ± 1.9 (18) -24.1 (mV) Data Table
Dorsal root ganglion cell Small isolectin B4 negative dorsal root ganglion cell spike threshold (mV) -25.6 ± 1.8 (17) -25.6 (mV) Data Table
Dorsal root ganglion cell Large dorsal root ganglion cell resting membrane potential (mV) -54.3 ± 1.9 (12) -54.3 (mV) Data Table
Dorsal root ganglion cell Large dorsal root ganglion cell spike amplitude (mV) 101.3 ± 6.5 (12) 101.3 (mV) Data Table
Dorsal root ganglion cell Medium dorsal root ganglion cell spike amplitude (mV) 97.3 ± 2.5 (36) 97.3 (mV) Data Table
Dorsal root ganglion cell Small isolectin B4 positive dorsal root ganglion cell spike amplitude (mV) 103.8 ± 3.4 (20) 103.8 (mV) Data Table
Dorsal root ganglion cell Small isolectin B4 negative dorsal root ganglion cell spike amplitude (mV) 104.6 ± 4.0 (23) 104.6 (mV) Data Table
Dorsal root ganglion cell Large dorsal root ganglion cell spike width (ms) 2.0 ± 0.39 (12) 2.0 (ms) Data Table
Dorsal root ganglion cell Medium dorsal root ganglion cell spike width (ms) 2.05 ± 0.15 (36) 2.05 (ms) Data Table
Dorsal root ganglion cell Small isolectin B4 positive dorsal root ganglion cell spike width (ms) 1.86 ± 0.12 (20) 1.86 (ms) Data Table
Dorsal root ganglion cell Small isolectin B4 negative dorsal root ganglion cell spike width (ms) 3.29 ± 0.43 (23) 3.29 (ms) Data Table
Dorsal root ganglion cell Large dorsal root ganglion cell spike max rise slope (mV/ms) 124.5 ± 17.2 (12) 124.5 (mV/ms) Data Table
Dorsal root ganglion cell Medium dorsal root ganglion cell resting membrane potential (mV) -61.4 ± 0.8 (36) -61.4 (mV) Data Table
Dorsal root ganglion cell Medium dorsal root ganglion cell spike max rise slope (mV/ms) 95.5 ± 5.8 (36) 95.5 (mV/ms) Data Table
Dorsal root ganglion cell Small isolectin B4 positive dorsal root ganglion cell spike max rise slope (mV/ms) 110.0 ± 7.4 (20) 110.0 (mV/ms) Data Table
Dorsal root ganglion cell Small isolectin B4 negative dorsal root ganglion cell spike max rise slope (mV/ms) 107.9 ± 9.7 (23) 107.9 (mV/ms) Data Table
Dorsal root ganglion cell Large dorsal root ganglion cell spike max decay slope (mV/ms) -68.2 ± 8.8 (12) 68.2 (mV/ms) Data Table
Dorsal root ganglion cell Medium dorsal root ganglion cell spike max decay slope (mV/ms) -52.1 ± 2.5 (36) 52.1 (mV/ms) Data Table
Dorsal root ganglion cell Small isolectin B4 positive dorsal root ganglion cell spike max decay slope (mV/ms) -57.9 ± 3.3 (20) 57.9 (mV/ms) Data Table
Dorsal root ganglion cell Small isolectin B4 negative dorsal root ganglion cell spike max decay slope (mV/ms) -49.0 ± 4.5 (23) 49.0 (mV/ms) Data Table
Dorsal root ganglion cell Large dorsal root ganglion cell AHP amplitude (mV) -16.9 ± 1.8 (12) 16.9 (mV) Data Table
Dorsal root ganglion cell Medium dorsal root ganglion cell AHP amplitude (mV) -17.7 ± 0.8 (36) 17.7 (mV) Data Table
Dorsal root ganglion cell Small isolectin B4 positive dorsal root ganglion cell resting membrane potential (mV) -58.5 ± 1.4 (20) -58.5 (mV) Data Table
Dorsal root ganglion cell Small isolectin B4 positive dorsal root ganglion cell AHP amplitude (mV) -20.1 ± 0.9 (20) 20.1 (mV) Data Table
Dorsal root ganglion cell Small isolectin B4 negative dorsal root ganglion cell AHP amplitude (mV) -15.4 ± 1.4 (23) 15.4 (mV) Data Table
Dorsal root ganglion cell Small isolectin B4 negative dorsal root ganglion cell resting membrane potential (mV) -57.0 ± 1.4 (23) -57.0 (mV) Data Table
Dorsal root ganglion cell Large dorsal root ganglion cell rheobase (nA) 0.39 ± 0.05 (12) 390.0 (pA) Data Table
Dorsal root ganglion cell Medium dorsal root ganglion cell rheobase (nA) 0.49 ± 0.03 (36) 490.0 (pA) Data Table
Dorsal root ganglion cell Small isolectin B4 positive dorsal root ganglion cell rheobase (nA) 0.37 ± 0.03 (20) 370.0 (pA) Data Table
Dorsal root ganglion cell Small isolectin B4 negative dorsal root ganglion cell rheobase (nA) 0.27 ± 0.02 (23) 270.0 (pA) Data Table
Dorsal root ganglion cell Large dorsal root ganglion cell input resistance (MΩ) 192.0 ± 30.0 (12) 192.0 (MΩ) Data Table
Dorsal root ganglion cell Medium dorsal root ganglion cell input resistance (MΩ) 330.0 ± 23.0 (36) 330.0 (MΩ) Data Table
Dorsal root ganglion cell Small isolectin B4 positive dorsal root ganglion cell input resistance (MΩ) 453.0 ± 35.0 (20) 453.0 (MΩ) Data Table
Dorsal root ganglion cell Small isolectin B4 negative dorsal root ganglion cell input resistance (MΩ) 603.0 ± 50.0 (23) 603.0 (MΩ) Data Table