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Article: Cortical slow oscillatory activity is reflected in the membrane potential and spike trains of striatal neurons in rats with chronic nigrostriatal lesions.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Tseng KY; Kasanetz F; Kargieman L; Riquelme LA; Murer MG J. Neurosci., 2001
Characterization of the response of intracellularly recorded striatal neurons to cortical stimulation in control and 6-hydroxydopamine-lesioned rats
| Control | 6-OHDA | |
|---|---|---|
| Fast dPSP | ||
| Time to the peak (msec) | 20.6 ± 0.7 | 21.7 ± 0.9 |
| Amplitude (mV) | 16.4 ± 1.6 | 15.0 ± 2.3 |
| Long-lasting hyperpolarization | ||
| Duration (msec) | 415.1 ± 30.3 | 293.2 ± 16.82-a |
| Latency (msec) | 58.1 ± 4.5 | 64.1 ± 7.3 |
| Membrane potential in steady-state (mV) | −91.8 ± 1.9 | −83.8 ± 2.32-b |
| Long-lasting depolarization | ||
| Duration (msec) | 521.7 ± 97.1 | 555.8 ± 138.7 |
| Latency (msec) | 466.9 ± 30.3 | 352.6 ± 16.92-c |
| Membrane potential in steady state (mV) | −76.2 ± 1.9 | −71.7 ± 1.92-d |
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Data are mean ± SEM of n = 8–20 neuronal responses. The responses were evoked by single pulse cortical stimulation (400 μA square wave pulses at 0.5 Hz).
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↵F2-a p = 0.0007, two-tailed Student's t test.
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↵F2-b p = 0.019, two-tailed Student's t test.
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↵F2-c p = 0.0013, two-tailed Student's t test.
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↵F2-d NS (p = 0.102), two-tailed Student's t test.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neostriatum medium spiny neuron | resting membrane potential (mV) | -91.8 ± 1.9 | -91.8 (mV) | Data Table | |
| Neostriatum medium spiny neuron | resting membrane potential (mV) | -76.2 ± 1.9 | -76.2 (mV) | Data Table |