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Article: Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Le Bé JV; Silberberg G; Wang Y; Markram H
Cereb. Cortex, 2007


Table 1

Electrophysiological properties of the CCPs and the TTCs

CCP (n = 22) TTC (n = 35)
Access (MΩ) 23.7 ± 5.4 21.9 ± 4.9
First AP in train
    AP amplitude (mV) 59.6 ± 5.5 63.0 ± 5.3*
    AP duration (ms) 4.29 ± 0.64 3.09 ± 0.52***
    AP duration at half amplitude (ms) 1.93 ± 0.31 1.35 ± 0.24***
    AP rise time (ms) 1.05 ± 0.16 0.80 ± 0.15***
    AP fall time (ms) 3.24 ± 0.55 2.29 ± 0.41***
    Fast AHP (mV) -2.2 ± 4.1 3.7 ± 3.5***
Second AP in train
    AP amplitude (mV) 45 ± 11 63 ± 6***
    AP duration (ms) 7.2 ± 1.2 6.0 ± 0.7***
    AP duration at half amplitude (ms) 2.87 ± 0.88 2.06 ± 0.35***
    AP rise time (ms) 1.99 ± 0.39 1.25 ± 0.26***
    AP fall time (ms) 5.2 ± 1.1 4.7 ± 0.7
IV analysis
    Time to hyperpol peak (s) 0.194 ± 0.033 0.417 ± 0.430**
    Input resistance for peak (MΩ) 228 ± 92 64 ± 19***
    Input resistance for steady state (MΩ) 183 ± 67 51 ± 15***
    Maximum sag (mV) 6.6 ± 3.9 5.8 ± 3.4
Decay time constant for Δ pulse (ms) 20.0 ± 5.8 17.5 ± 4.7
AP threshold (mV) -32.3 ± 5.6 -39.4 ± 2.6***
Slow AHP (mV) 7.1 ± 3.2 8.6 ± 2.9
Step current
    Average delay to first spike (s) 0.031 ± 0.013 0.026 ± 0.012
    Current-discharge slope (Hz nA-1) 27.6 ± 28.5 26.2 ± 5.7
    Initial burst interval (s) 0.052 ± 0.047 0.081 ± 0.049*

  • Note: Mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001, P value is from Student t-test; AHP = after hyperpolarization.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell spike amplitude (mV) 63.0 ± 5.3 (35) 63.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell spike width (ms) 4.29 ± 0.64 (22) 4.29 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell spike width (ms) 3.09 ± 0.52 (35) 3.09 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell spike half-width (ms) 1.93 ± 0.31 (22) 1.93 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell spike half-width (ms) 1.35 ± 0.24 (35) 1.35 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell spike rise time (ms) 1.05 ± 0.16 (22) 1.05 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell spike rise time (ms) 0.8 ± 0.15 (35) 0.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell spike decay time (ms) 3.24 ± 0.55 (22) 3.24 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell spike decay time (ms) 2.29 ± 0.41 (35) 2.29 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell fast AHP amplitude (mV) -2.2 ± 4.1 (22) 2.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell fast AHP amplitude (mV) 3.7 ± 3.5 (35) 3.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell access resistance (MΩ) 23.7 ± 5.4 (22) 23.7 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell input resistance (MΩ) 183.0 ± 67.0 (22) 183.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell input resistance (MΩ) 51.0 ± 15.0 (35) 51.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell sag amplitude (mV) 6.6 ± 3.9 (22) 6.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell sag amplitude (mV) 5.8 ± 3.4 (35) 5.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell membrane time constant (ms) 20.0 ± 5.8 (22) 20.0 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell membrane time constant (ms) 17.5 ± 4.7 (35) 17.5 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell spike threshold (mV) -32.3 ± 5.6 (22) -32.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell access resistance (MΩ) 21.9 ± 4.9 (35) 21.9 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell spike threshold (mV) -39.4 ± 2.6 (35) -39.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell slow AHP amplitude (mV) 7.1 ± 3.2 (22) 7.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell slow AHP amplitude (mV) 8.6 ± 2.9 (35) 8.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell FI slope 27.6 ± 28.5 (22) 27.6 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V thick tufted pyramidal cell FI slope 26.2 ± 5.7 (35) 26.2 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer V corticocallosal projecting pyramidal cell spike amplitude (mV) 59.6 ± 5.5 (22) 59.6 (mV) Data Table