Table 1
Intrinsic physiological properties of WT and reeler MCs
| WT | Reeler | P value | |
| Resting membrane potential (Vm) | -62.9 ± 0.8 (66)a | -61.7 ± 0.5 (81) | 0.535 |
| Input resistance (MΩ) | 270 ± 19 (22)a | 247 ± 11 (49) | 0.250 |
| Membrane time constant (ms) | 48 ± 3 (24)a | 49 ± 2 (48) | 0.582 |
| Membrane capacitance (pF) | 47 ± 2 (46)a | 49 ± 1 (80) | 0.445 |
| AP | |||
| Threshold (ms) | -41.8 ± 0.7 (18)b | -41.3 ± 0.3 (81) | 0.680 |
| Amplitude (mV) | 90.2 ± 1.0 (18)b | 91.8 ± 0.5 (81) | 0.078 |
| Half-height duration (ms) | 0.70 ± 0.02 (18)b | 0.64 ± 0.01 (81) | 0.039 |
| Maximum rate of rise (mV/ms) | 401 ± 16 (18)b | 452 ± 8 (81) | 0.001* |
| Maximum rate of repolarization (mV/ms) | 118 ± 4 (18)b | 130 ± 2 (81) | 0.017 |
| Afterhyperpolarization (mV) | 7.1 ± 0.4 (18)b | 9.4 ± 0.3 (81) | <0.001* |
| Discharge frequency | 38 ± 5 (11)b | 31 ± 2 (54) | 0.270 |
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Note: Values are expressed as mean ± standard error of the mean; number of cells is indicated in parenthesis. Asterisks indicate significant differences between the WT and reeler groups assessed using the Holm-Bonferroni correction.
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↵a Pooled WT data set.
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↵b WT littermate data only. For further details, see Materials and Methods.