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Article: Acetylcholine encodes long-lasting presynaptic plasticity at glutamatergic synapses in the dorsal striatum after repeated amphetamine exposure.

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Wang W; Darvas M; Storey GP; Bamford IJ; Gibbs JT; Palmiter RD; Bamford NS
J. Neurosci., 2013


Table 1.

Passive and active membrane properties of MSNs, TANs, and PLTS interneurons

MSN TAN PLTS*
Passive membrane properties
    Ra, MΩ 14.0 ± 0.7 (114) 20.8 ± 0.7 (34) 15.9 ± 1.4 (10)
    Rm, MΩ 139.3 ± 15.1 (114) 337.2 ± 22.3 (50) 693.6 ± 82.6 (10)
    Cm, pF 108.9 ± 4.6 (114) 113.0 ± 5.1 (50) 38.6 ± 4.5 (10)
    RMP, mV -73.2 ± 2.2 (14) -57.8 ± 1.1 (50) -58.6 ± 2.3 (15)
AP properties
    #APs 5.6 ± 0.8 (14) 14.4 ± 1.1 (50) 9.9 ± 1.2 (14)
    Amplitude, mV 77.7 ± 3.3 (14) 59.6 ± 2.3 (50) 41.5 ± 1.8 (14)
    AP half-width, ms 0.8 ± 0.1 (14) 2.5 ± 0.1 (50) 1.7 ± 0.1 (14)
    AHP, mV -11.1 ± 0.8 (14) -8.2 ± 0.6 (50) -7.1 ± 0.5 (14)
    Input current at threshold, pA 368 ± 29 (14) 107 ± 18 (50) 25 ± 4 (14)
    Threshold, mV -34.4 ± 0.7 (14) -45.4 ± 1.6 (50) -35.7 ± 1.4 (14)

  • Properties of TANs are compared with MSNs and with persistent low-threshold spike (PLTS) striatal interneurons that can be spontaneously active in cell-attached configuration. Compared with PLTS cells, TANs have a lower membrane resistance (Rm), higher membrane capacitance (Cm), and longer action potential duration (AP) half-width. Values are means ± SE. Group n is shown in parentheses. Ra indicates access resistance; RMP, resting membrane potential; #APs, number of action potentials counted over 400 ms at the third trace exhibiting Aps; AHP, afterhyperpolarization potential.

  • ↵*Data for PLTS cells were obtained from Wang et al., 2013.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum medium spiny neuron input resistance (MΩ) 139.3 ± 15.1 (114) 139.3 (MΩ) Data Table
Neostriatum gabaergic interneuron Neostriatum tonically active interneuron input resistance (MΩ) 337.2 ± 22.3 (50) 337.2 (MΩ) Data Table
Neostriatum gabaergic interneuron Neostriatum persistent low-threshold spike interneurons input resistance (MΩ) 693.6 ± 82.6 (10) 693.6 (MΩ) Data Table
Neostriatum medium spiny neuron cell capacitance (pF) 108.9 ± 4.6 (114) 108.9 (pF) Data Table
Neostriatum gabaergic interneuron Neostriatum tonically active interneuron cell capacitance (pF) 113.0 ± 5.1 (50) 113.0 (pF) Data Table
Neostriatum gabaergic interneuron Neostriatum persistent low-threshold spike interneurons cell capacitance (pF) 38.6 ± 4.5 (10) 38.6 (pF) Data Table
Neostriatum medium spiny neuron resting membrane potential (mV) -73.2 ± 2.2 (14) -73.2 (mV) Data Table
Neostriatum gabaergic interneuron Neostriatum tonically active interneuron resting membrane potential (mV) -57.8 ± 1.1 (50) -57.8 (mV) Data Table
Neostriatum gabaergic interneuron Neostriatum persistent low-threshold spike interneurons resting membrane potential (mV) -58.6 ± 2.3 (15) -58.6 (mV) Data Table
Neostriatum medium spiny neuron spike amplitude (mV) 77.7 ± 3.3 (14) 77.7 (mV) Data Table
Neostriatum gabaergic interneuron Neostriatum tonically active interneuron spike amplitude (mV) 59.6 ± 2.3 (50) 59.6 (mV) Data Table
Neostriatum gabaergic interneuron Neostriatum persistent low-threshold spike interneurons spike amplitude (mV) 41.5 ± 1.8 (14) 41.5 (mV) Data Table
Neostriatum medium spiny neuron spike half-width (ms) 0.8 ± 0.1 (14) 0.8 (ms) Data Table
Neostriatum gabaergic interneuron Neostriatum tonically active interneuron spike half-width (ms) 2.5 ± 0.1 (50) 2.5 (ms) Data Table
Neostriatum gabaergic interneuron Neostriatum persistent low-threshold spike interneurons spike half-width (ms) 1.7 ± 0.1 (14) 1.7 (ms) Data Table
Neostriatum medium spiny neuron AHP amplitude (mV) -11.1 ± 0.8 (14) 11.1 (mV) Data Table
Neostriatum gabaergic interneuron Neostriatum tonically active interneuron AHP amplitude (mV) -8.2 ± 0.6 (50) 8.2 (mV) Data Table
Neostriatum gabaergic interneuron Neostriatum persistent low-threshold spike interneurons AHP amplitude (mV) -7.1 ± 0.5 (14) 7.1 (mV) Data Table
Neostriatum medium spiny neuron rheobase (pA) 368.0 ± 29.0 (14) 368.0 (pA) Data Table
Neostriatum gabaergic interneuron Neostriatum tonically active interneuron rheobase (pA) 107.0 ± 18.0 (50) 107.0 (pA) Data Table
Neostriatum gabaergic interneuron Neostriatum persistent low-threshold spike interneurons rheobase (pA) 25.0 ± 4.0 (14) 25.0 (pA) Data Table
Neostriatum medium spiny neuron spike threshold (mV) -34.4 ± 0.7 (14) -34.4 (mV) Data Table
Neostriatum gabaergic interneuron Neostriatum tonically active interneuron spike threshold (mV) -45.4 ± 1.6 (50) -45.4 (mV) Data Table
Neostriatum gabaergic interneuron Neostriatum persistent low-threshold spike interneurons spike threshold (mV) -35.7 ± 1.4 (14) -35.7 (mV) Data Table
Neostriatum medium spiny neuron access resistance (MΩ) 14.0 ± 0.7 (114) 14.0 (MΩ) Data Table
Neostriatum gabaergic interneuron Neostriatum tonically active interneuron access resistance (MΩ) 20.8 ± 0.7 (34) 20.8 (MΩ) Data Table
Neostriatum gabaergic interneuron Neostriatum persistent low-threshold spike interneurons access resistance (MΩ) 15.9 ± 1.4 (10) 15.9 (MΩ) Data Table