AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Functional analysis of a migraine-associated TRESK K+ channel mutation.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Liu P; Xiao Z; Ren F; Guo Z; Chen Z; Zhao H; Cao YQ
J. Neurosci., 2013


Table 1.

Intrinsic properties of small-diameter TG neurons expressing mutant TRESK subunits

Diameter (μm) Capacitance (pF) Rin (MΩ) Vrest (mV) Rheobase (pA) AP threshold (mV) AP amplitude (mV) AP half-width (ms) AHP amplitude (mV) Cell number
IB4-negative neurons
    Control 20.3 ± 0.2 25.2 ± 0.7 942 ± 78 -52.9 ± 0.5 75.0 ± 3.0 -14.4 ± 0.6 112.2 ± 1.4 4.9 ± 0.2 -14.2 ± 0.5 14
    Mutant 19.5 ± 0.2 22.5 ± 0.7 1123 ± 48 -52.1 ± 0.6 38.5 ± 1.8* -23.2 ± 0.6* 107.9 ± 2.1 4.5 ± 0.3 -12.0 ± 0.4 12
IB4-positive neurons
    Control 19.9 ± 0.2 22.4 ± 1.0 1358 ± 166 -53.5 ± 0.7 77.3 ± 4.5 -17.1 ± 0.9 104.4 ± 2.4 4.6 ± 0.1 -14.9 ± 0.5 11
    Mutant 18.6 ± 0.2 19.5 ± 0.7 1388 ± 94 -52.4 ± 0.6 40.0 ± 2.3* -18.7 ± 1.2 113.3 ± 2.2 4.1 ± 0.2 -15.4 ± 0.3 10

  • Neurons in the control group express DsRed protein alone; the mutant group contains TG neurons coexpressing DsRed protein and MT TRESK subunits. Rin was calculated by measuring the change of membrane potential in response to a 20 pA hyperpolarizing current injection from Vrest.

  • ↵*p < 0.05 compared with the corresponding control group by two-tailed t test.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Trigeminal nucleus principal cell cell diameter (μm) 20.3 ± 0.2 (14) 20.3 (um) Data Table
Trigeminal nucleus principal cell cell capacitance (pF) 25.2 ± 0.7 (14) 25.2 (pF) Data Table
Trigeminal nucleus principal cell input resistance (MΩ) 942.0 ± 78.0 (14) 942.0 (MΩ) Data Table
Trigeminal nucleus principal cell resting membrane potential (mV) -52.9 ± 0.5 (14) -52.9 (mV) Data Table
Trigeminal nucleus principal cell rheobase (pA) 75.0 ± 3.0 (14) 75.0 (pA) Data Table
Trigeminal nucleus principal cell spike threshold (mV) -14.4 ± 0.6 (14) -14.4 (mV) Data Table
Trigeminal nucleus principal cell spike amplitude from resting (mV) 112.2 ± 1.4 (14) 112.2 (mV) Data Table
Trigeminal nucleus principal cell spike half-width (ms) 4.9 ± 0.2 (14) 4.9 (ms) Data Table
Trigeminal nucleus principal cell AHP amplitude (mV) -14.2 ± 0.5 (14) 14.2 (mV) Data Table