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Article: Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression.

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Simkin D; Hattori S; Ybarra N; Musial TF; Buss EW; Richter H; Oh MM; Nicholson DA; Disterhoft JF
J. Neurosci., 2015


Table 1.

Passive intrinsic properties were not different with age

Group Vrest (mV) Rn at Vrest (mΩ) Rs at Vrest (mΩ) Saga (mV) AP amplitude from Vh (mV) Vthresh (mV)
Young (n = 52) -68.97 ± 0.75 85.01 ± 4.41 21.56 ± 0.77 -2.28 ± 0.13 83.74 ± 1.1 (31) -48.26 ± 0.86 (31)
Aged (n = 44) -67.56 ± 1.02 79.99 ± 4.73 21.33 ± 1.08 -2.32 ± 0.17 86.11 ± 1.19 (29) -47.89 ± 0.87 (29)

  • ↵aAfter -350 pA current injection. Vrest, Resting potential; RN, input resistance; RS, series resistance; Vh, holding potential; Vthresh, AP threshold potential.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA3 pyramidal cell input resistance (mΩ) 79.99 ± 4.73 (44) 79.99 (MΩ) Data Table
Hippocampus CA3 pyramidal cell access resistance (mΩ) 21.33 ± 1.08 (44) 21.33 (MΩ) Data Table
Hippocampus CA3 pyramidal cell sag amplitude (mV) -2.32 ± 0.17 (44) -2.32 (mV) Data Table
Hippocampus CA3 pyramidal cell spike amplitude from resting (mV) 86.11 ± 1.19 (29) 86.11 (mV) Data Table
Hippocampus CA3 pyramidal cell spike threshold (mV) -47.89 ± 0.87 (29) -47.89 (mV) Data Table
Hippocampus CA3 pyramidal cell resting membrane potential (mV) -68.97 ± 0.75 (52) -68.97 (mV) Data Table
Hippocampus CA3 pyramidal cell input resistance (mΩ) 85.01 ± 4.41 (52) 85.01 (MΩ) Data Table
Hippocampus CA3 pyramidal cell access resistance (mΩ) 21.56 ± 0.77 (52) 21.56 (MΩ) Data Table
Hippocampus CA3 pyramidal cell sag amplitude (mV) -2.28 ± 0.13 (52) -2.28 (mV) Data Table
Hippocampus CA3 pyramidal cell spike amplitude from resting (mV) 83.74 ± 1.1 (31) 83.74 (mV) Data Table
Hippocampus CA3 pyramidal cell spike threshold (mV) -48.26 ± 0.86 (31) -48.26 (mV) Data Table
Hippocampus CA3 pyramidal cell resting membrane potential (mV) -67.56 ± 1.02 (44) -67.56 (mV) Data Table