AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Reduced chemical and electrical connections of fast-spiking interneurons in experimental cortical dysplasia.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Zhou FW; Roper SN
J. Neurophysiol., 2014


Table 1.

Intrinsic properties

FS-PV interneuronsPyramidal neuronsSpiny stellate neurons
ControlCDControlCDControlCD
n23514681527245
Vrest, mV-65.2 ± 0.9-64.4 ± 1.1-68.5 ± 1.1-67.5 ± 0.8-67.3 ± 1.0-66.8 ± 1.2
Rin, MΩ171.5 ± 9.6*†182.2 ± 10.1‡§215.7 ± 12.3220.7 ± 13.5226.9 ± 10.8221.6 ± 12.7
Time constant, ms13.9 ± 0.9*†14.4 ± 1.0‡§19.5 ± 1.220.2 ± 1.421.7 ± 1.123.1 ± 1.2
AP threshold, mV-41.6 ± 0.8-42.0 ± 0.7-39.5 ± 0.6-39.1 ± 0.7-38.8 ± 0.9-39.2 ± 0.8
AP half-width, ms0.42 ± 0.02*†0.44 ± 0.04‡§1.12 ± 0.071.15 ± 0.091.17 ± 0.081.22 ± 0.07
AP amplitude, mV63.7 ± 1.164.4 ± 0.967.1 ± 1.466.3 ± 1.565.8 ± 1.164.9 ± 1.2
F-I slope, Hz/nA344.8 ± 15.2*†355.6 ± 21.3‡§63.7 ± 6.168.4 ± 6.972.2 ± 5.779.3 ± 7.0
FRMax, Hz204.5 ± 18.3*†211.2 ± 19.1‡§51.2 ± 8.253.8 ± 9.554.2 ± 7.956.4 ± 9.2
Adaptation1.03 ± 0.04*†1.05 ± 0.06‡§0.29 ± 0.070.32 ± 0.090.23 ± 0.080.24 ± 0.07

  • Values are means ± SE of properties measured in control tissue or dysplastic cortex (CD); n = the total number of neurons recorded in pairs with or without connections. FS-PV interneurons, fast-spiking parvalbumin-immunoreactive interneurons; Vrest, resting membrane potential; Rin, input resistance, obtained by applying a 100-ms hyperpolarizing voltage step of 10 mV from a holding potential of -65 mV in whole cell voltage-clamp mode; AP, action potential; F-I slope, slope of the relationship between firing rate and injected current intensity; FRMax, maximal steady-state firing rate; adaptation, spike frequency adaptation.

  • ↵* P < 0.01 vs. control pyramidal neurons;

  • ↵† P < 0.01 vs. control spiny stellate neurons;

  • ↵‡ P < 0.01 vs. CD pyramidal neurons;

  • ↵§ P < 0.01 vs. CD spiny stellate neurons.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Neocortex layer 4 pyramidal neurons resting membrane potential (mV) -68.5 ± 1.1 (81) -68.5 (mV) Data Table
Neocortex stellate cell Neocortex excitatory spiny stellate neurons resting membrane potential (mV) -67.3 ± 1.0 (72) -67.3 (mV) Data Table
Neocortex uncharacterized cell Neocortex fast-spiking parvalbumin-immunoreactive interneurons input resistance (MΩ) 171.5 ± 9.6 (235) 171.5 (MΩ) Data Table
Other Neocortex layer 4 pyramidal neurons input resistance (MΩ) 215.7 ± 12.3 (81) 215.7 (MΩ) Data Table
Neocortex stellate cell Neocortex excitatory spiny stellate neurons input resistance (MΩ) 226.9 ± 10.8 (72) 226.9 (MΩ) Data Table
Neocortex uncharacterized cell Neocortex fast-spiking parvalbumin-immunoreactive interneurons membrane time constant (ms) 13.9 ± 0.9 (235) 13.9 (ms) Data Table
Other Neocortex layer 4 pyramidal neurons membrane time constant (ms) 19.5 ± 1.2 (81) 19.5 (ms) Data Table
Neocortex stellate cell Neocortex excitatory spiny stellate neurons membrane time constant (ms) 21.7 ± 1.1 (72) 21.7 (ms) Data Table
Neocortex uncharacterized cell Neocortex fast-spiking parvalbumin-immunoreactive interneurons spike threshold (mV) -41.6 ± 0.8 (235) -41.6 (mV) Data Table
Other Neocortex layer 4 pyramidal neurons spike threshold (mV) -39.5 ± 0.6 (81) -39.5 (mV) Data Table
Neocortex stellate cell Neocortex excitatory spiny stellate neurons spike threshold (mV) -38.8 ± 0.9 (72) -38.8 (mV) Data Table
Neocortex uncharacterized cell Neocortex fast-spiking parvalbumin-immunoreactive interneurons spike half-width (ms) 0.42 ± 0.02 (235) 0.42 (ms) Data Table
Other Neocortex layer 4 pyramidal neurons spike half-width (ms) 1.12 ± 0.07 (81) 1.12 (ms) Data Table
Neocortex stellate cell Neocortex excitatory spiny stellate neurons spike half-width (ms) 1.17 ± 0.08 (72) 1.17 (ms) Data Table
Neocortex uncharacterized cell Neocortex fast-spiking parvalbumin-immunoreactive interneurons spike amplitude (mV) 63.7 ± 1.1 (235) 63.7 (mV) Data Table
Other Neocortex layer 4 pyramidal neurons spike amplitude (mV) 67.1 ± 1.4 (81) 67.1 (mV) Data Table
Neocortex stellate cell Neocortex excitatory spiny stellate neurons spike amplitude (mV) 65.8 ± 1.1 (72) 65.8 (mV) Data Table
Neocortex uncharacterized cell Neocortex fast-spiking parvalbumin-immunoreactive interneurons FI slope (Hz/nA) 344.8 ± 15.2 (235) 344.8 (Hz/nA) Data Table
Other Neocortex layer 4 pyramidal neurons FI slope (Hz/nA) 63.7 ± 6.1 (81) 63.7 (Hz/nA) Data Table
Neocortex stellate cell Neocortex excitatory spiny stellate neurons FI slope (Hz/nA) 72.2 ± 5.7 (72) 72.2 (Hz/nA) Data Table
Neocortex uncharacterized cell Neocortex fast-spiking parvalbumin-immunoreactive interneurons maximum firing rate (Hz) 204.5 ± 18.3 (235) 204.5 (Hz) Data Table
Other Neocortex layer 4 pyramidal neurons maximum firing rate (Hz) 51.2 ± 8.2 (81) 51.2 (Hz) Data Table
Neocortex stellate cell Neocortex excitatory spiny stellate neurons maximum firing rate (Hz) 54.2 ± 7.9 (72) 54.2 (Hz) Data Table
Neocortex uncharacterized cell Neocortex fast-spiking parvalbumin-immunoreactive interneurons adaptation ratio 1.03 ± 0.04 (235) 1.03 (ratio) Data Table
Other Neocortex layer 4 pyramidal neurons adaptation ratio 0.29 ± 0.07 (81) 0.29 (ratio) Data Table
Neocortex stellate cell Neocortex excitatory spiny stellate neurons adaptation ratio 0.23 ± 0.08 (72) 0.23 (ratio) Data Table
Neocortex uncharacterized cell Neocortex fast-spiking parvalbumin-immunoreactive interneurons resting membrane potential (mV) -65.2 ± 0.9 (235) -65.2 (mV) Data Table