Article: Repeated cocaine exposure increases fast-spiking interneuron excitability in the rat medial prefrontal cortex.

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Campanac E; Hoffman DA
J. Neurophysiol., 2013

Table 1.

Passive and active membrane properties of FS-IN in layer 5 mPFC neurons from saline- and cocaine-treated rats after long-term withdrawal

Pretreatment	Saline	Cocaine	P Value
n	19	18
Passive membrane properties
RMP, mV	-78.03 ± 0.98	-75.76 ± 0.91	ns
Input resistance, MΩ	103.58 ± 4.65	131.25 ± 8.29	<0.05^*
Active membrane properties
Rheobase, pA	258.60 ± 13.41	169.63 ± 13.46	<0.001^*
First spike parameters @ rheobase
Onset, ms	206.72 ± 51.79	258.78 ± 49.98	ns
Threshold, mV	-40.73 ± 1.07	-41.28 ± 3.36	ns
Rise time 10-90%, ms	0.29 ± 0.01	0.33 ± 0.04	ns
Maximum, mV	9.86 ± 1.38	13.01 ± 1.56	ns
AHP amplitude, mV	-21.72 ± 1.03	-19.79 ± 0.88	ns
Width, ms	0.56 ± 0.02	0.54 ± 0.01	ns
First spike parameters @ 15-Hz firing
Onset, ms	42.19 ± 16.87	70.02 ± 29.59	ns
Threshold, mV	-44.64 ± 1.35	-46.84 ± 1.44	ns
Rise time 10-90%, ms	0.34 ± 0.04	0.34 ± 0.03	ns
Maximum, mV	9.05 ± 1.75	11.16 ± 1.65	ns
AHP amplitude, mV	-15.78 ± 1.24	-16.32 ± 1.61	ns
Width, ms	0.57 ± 0.02	0.55 ± 0.0	ns
Accommodation index	13.08 ± 4.01	5.36 ± 1.34	ns

Values are means ± SE; n, no. of neurons (saline, n = 19, 8 rats; cocaine, n = 18, 7 rats). RMP, resting membrane potential; AHP, afterhyperpolarization. Parameters of the first spike were measured during step current injections corresponding at the rheobase or when neurons fired at approximately 15 Hz (i.e., 12-18 action potentials during the 1-s current step). Accommodation is defined by (t_{spike 2} - t_{spike 1})/(t_{spike n} - t_{spike n-1}), where t is time.
↵* Significant difference. ns, Not significant.

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Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Neocortex interneuron deep	Medial prefrontal cortex layer V fast-spiking interneurons	input resistance (MΩ)	103.58 ± 4.65 (19)	103.58 (MΩ)	Data Table
Neocortex interneuron deep	Medial prefrontal cortex layer V fast-spiking interneurons	rheobase (pA)	258.6 ± 13.41 (19)	258.6 (pA)	Data Table
Neocortex interneuron deep	Medial prefrontal cortex layer V fast-spiking interneurons	spike threshold (mV)	-40.73 ± 1.07 (19)	-40.73 (mV)	Data Table
Neocortex interneuron deep	Medial prefrontal cortex layer V fast-spiking interneurons	spike rise time (ms)	0.29 ± 0.01 (19)	0.29 (ms)	Data Table
Neocortex interneuron deep	Medial prefrontal cortex layer V fast-spiking interneurons	input resistance (mV)	9.86 ± 1.38 (19)	--	Data Table
Neocortex interneuron deep	Medial prefrontal cortex layer V fast-spiking interneurons	AHP amplitude (mV)	-21.72 ± 1.03 (19)	21.72 (mV)	Data Table
Neocortex interneuron deep	Medial prefrontal cortex layer V fast-spiking interneurons	spike half-width (ms)	0.56 ± 0.02 (19)	0.56 (ms)	Data Table
Neocortex interneuron deep	Medial prefrontal cortex layer V fast-spiking interneurons	spike peak (mV)	9.05 ± 1.75 (19)	9.05 (mV)	Data Table
Neocortex interneuron deep	Medial prefrontal cortex layer V fast-spiking interneurons	resting membrane potential (mV)	-78.03 ± 0.98 (19)	-78.03 (mV)	Data Table
Neocortex interneuron deep	Medial prefrontal cortex layer V fast-spiking interneurons	adaptation ratio (other)	13.08 ± 4.01 (19)	13.08 (None)	Data Table