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Article: Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine.

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Guan D; Armstrong WE; Foehring RC
J. Neurophysiol., 2015


Table 1.

RMP, Rin, and rheobase

Etv1GltLayer 2/3
RMP, mV-75 ± 0.4 (102)†-73 ± 0.4 (67)*†-82 ± 0.8 (35)
Rin, MΩ138 ± 6 (102)138 ± 5.6 (68)139 ± 13 (35)
Sag, %19 ± 1.0 (69)†25 ± 1.2 (37)*†6.5 ± 0.9 (28)*
Sag TTP, ms58 ± 2.0 (59)44 ± 1.9 (37)*†57 ± 5.4 (20)
Rheobase, pA172 ± 12 (76)97 ± 8 (62)*†246 ± 28 (25)

  • Data are presented as means ± SE (n, number of cells).

  • ↵* Glt significantly different from etv1 (P < 0.05, unpaired t-test).

  • ↵† Significantly different from layer 2/3 (ANOVA with Tukey's post hoc test). RMP, resting membrane potential; Rin, peak input resistance; Sag TTP, time to peak voltage deflection.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons sag ratio 19.0 ± 1.0 (69) 0.19 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons sag ratio 25.0 ± 1.2 (37) 0.25 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons sag ratio 6.5 ± 0.9 (28) 0.065 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons rheobase (pA) 172.0 ± 12.0 (76) 172.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons rheobase (pA) 97.0 ± 8.0 (62) 97.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons resting membrane potential (mV) -75.0 ± 0.4 (102) -75.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons rheobase (pA) 246.0 ± 28.0 (25) 246.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons resting membrane potential (mV) -73.0 ± 0.4 (67) -73.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons resting membrane potential (mV) -82.0 ± 0.8 (35) -82.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons input resistance (MΩ) 138.0 ± 6.0 (102) 138.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons input resistance (MΩ) 138.0 ± 5.6 (68) 138.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons input resistance (MΩ) 139.0 ± 13.0 (35) 139.0 (MΩ) Data Table