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Article: Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism.

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Nenov MN; Tempia F; Denner L; Dineley KT; Laezza F
J. Neurophysiol., 2015


Table 3.

Comparison of active and passive properties of type I DG granule cells under different experimental conditions

Wild-type, n = 19Tg2576, n = 18Tg2576 + RSG, n = 26P
First peak latency, ms159.2 ± 21270.8 ± 23.2273.9 ± 25.20.002*
Itrh, pA25.3 ± 2.730.6 ± 2.726.9 ± 20.3*
Vtrh, mV-48.6 ± 1.1-43.9 ± 2-45.8 ± 1.20.03†
MRP, mV-59.6 ± 1.4-66.6 ± 1.6-64.7 ± 1.60.01*
Rin, MΩ443.3 ± 19.9419.1 ± 16.4440.6 ± 11.70.5*
τ, ms26.1 ± 1.532.6 ± 2.328.5 ± 1.60.02‡
Cm, pF62.3 ± 5.879.3 ± 5.666.9 ± 4.30.03†

  • Tg2576- and RSG-treated Tg2576 were compared with wild-type. Data are mean ± SE.

  • ↵* P values obtained with 1-way ANOVA and post hoc Dunnett test;

  • ↵† P values were obtained with post hoc Fisher test; and

  • ↵‡ P values obtained with post hoc Dunnett test.

  • Vtrh, voltage threshold; MRP, membrane resting potential; τ, time constant; Cm, membrane capacitance.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dentate gyrus granule cell Dentate gyrus inferior blade granule cell first spike latency (ms) 159.2 ± 21.0 (19) 159.2 (ms) Data Table
Dentate gyrus granule cell Dentate gyrus inferior blade granule cell rheobase (pA) 25.3 ± 2.7 (19) 25.3 (pA) Data Table
Dentate gyrus granule cell Dentate gyrus inferior blade granule cell spike threshold (mV) -48.6 ± 1.1 (19) -48.6 (mV) Data Table
Dentate gyrus granule cell Dentate gyrus inferior blade granule cell resting membrane potential (mV) -59.6 ± 1.4 (19) -59.6 (mV) Data Table
Dentate gyrus granule cell Dentate gyrus inferior blade granule cell input resistance (MΩ) 443.3 ± 19.9 (19) 443.3 (MΩ) Data Table
Dentate gyrus granule cell Dentate gyrus inferior blade granule cell membrane time constant (ms) 26.1 ± 1.5 (19) 26.1 (ms) Data Table
Dentate gyrus granule cell Dentate gyrus inferior blade granule cell cell capacitance (pF) 62.3 ± 5.8 (19) 62.3 (pF) Data Table