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Article: Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Dorris DM; Cao J; Willett JA; Hauser CA; Meitzen J J. Neurophysiol., 2015
Table 1.
Electrophysiological properties of male and female medium spiny neurons
| Property | Male | Female | Statistics (t/U, P) |
|---|---|---|---|
| Resting potential, mV | -81.2 ± 0.9 (33) | -80.0 ± 1.2 (31) | 0.52, 0.40 |
| Input resistance, MΩ | 448 ± 42 (33) | 465 ± 42 (31) | 484, 0.72 |
| Time constant of the membrane, ms | 23 ± 1 (33) | 27 ± 2 (31) | 1.74, 0.08 |
| Capacitance, pF | 61 ± 4 (33) | 69 ± 7 (31) | 476, 0.64 |
| Rectified range input Resistance, MΩ | 289 ± 29 (33) | 291 ± 26 (31) | 499, 0.87 |
| Inward rectification, MΩ | 156 ± 18 (33) | 175 ± 19 (31) | 0.72, 0.47 |
| % Inward rectification, % | 67 ± 2 (33) | 65 ± 2 (31) | 0.86, 0.39 |
| Sag index | 0.01 ± 0.00 (33) | 0.01 ± 0.00 (31) | 501, 0.89 |
| AP threshold, mV | -54 ± 1 (33) | -58 ± 1 (30) | 2.09, 0.040 |
| AP amplitude, mV | 72 ± 2 (33) | 75 ± 2 (30) | 1.26, 0.21 |
| AP width at half-peak, ms | 2.6 ± 0.1 (33) | 2.6 ± 0.l (30) | 0.27, 0.78 |
| AHP peak, mV | -10.8 ± 0.7 (33) | -8.3 ± 0.4 (30) | 3.04, 0.004 |
| AHP time to peak, ms | 52.9 ± 2.9 (33) | 47.9 ± 4.1 (30) | 1.18, 0.24 |
| Delay to first spike, ms | 313 ± 15 (33) | 307 ± 19 (30) | 0.24, 0.81 |
| Rheobase, nA | 0.040 ± 0.008 (33) | 0.025 ± 0.004 (30) | 356, 0.053 |
| FI slope, Hz/nA | 312.1 ± 18.5 (33) | 395.2 ± 20.4 (30) | 3.03, 0.004 |
Values are means ± SE. Numbers in parentheses indicate sample size. The sag index is unitless. None of these neurons fired spontaneous action potentials. Statistical differences between groups are depicted in boldface. Data were analyzed with t-tests or Mann-Whitney U-tests as appropriate.
AP, action potential; AHP, afterhyperpolarization; FI, frequency of evoked spikes to injected depolarization current.