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Article: Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Boehlen A; Henneberger C; Heinemann U; Erchova I J. Neurophysiol., 2013
Table 2.
Effects of the persistent sodium blocker losigamone and tetrodotoxin on somatic passive and active properties in layer II stellate cells
| Cell Properties | Control (Patch) | Losigamone (Patch) | Control (Sharp) | TTX (Sharp) |
|---|---|---|---|---|
| RMP, mV | -58.8 ± 0.6 | -58.0 ± 1.0 (11) | -65.0 ± 0.9 | -64.9 ± 0.8 (5) |
| Rinput, MΩ | -47.1 ± 2.7 | -47.0 ± 3.2 (11) | 29.4 ± 3.4 | 26.0 ± 2.6 (5) |
| Time constant at -100 pA, ms | 11.5 ± 0.7 | 13.9 ± 1.1† (11) | 8.3 ± 1.5 | 9.1 ± 0.6 (5) |
| Voltage threshold, mV | -42.1 ± 0.8 | -36.3 ± 1.4† (11) | -52.4 ± 0.7 | - |
| Rheobase, pA | 166.4 ± 19.2 | 248.2 ± 30.0† (11) | 170.0 ± 33.5 | - |
| Spike latency, ms | 58.3 ± 5.8 | 48.6 ± 6.5 (11) | 28.6 ± 2.9 | - |
| fAHP amplitude, mV | -7.0 ± 0.5 | -7.3 ± 0.6 (11) | -9.2 ± 1.0 | - |
| DAP amplitude, mV | 1.7 ± 0.4 | 0.9 ± 0.3* (11) | 1.3 ± 0.2 | - |
| mAHP amplitude, mV | -8.8 ± 0.4 | -8.6 ± 0.9 (11) | -7.4 ± 1.3 | - |
| mAHP amplitude DAP, mV | -3.6 ± 0.3 | -2.3 ± 0.5† (11) | -2.34 ± 0.2 | - |
| mAHP duration, ms | 70.0 ± 7.5 | 58.8 ± 10.2 (11) | 32.3 ± 2.9 | - |
| AP amplitude, mV | 75.7 ± 1.8 | 69.4 ± 2* (8) | 73.4 ± 1.4 | - |
| AP time to peak, ms | 0.65 ± 0.03 | 0.62 ± 0.01 (8) | - | - |
| AP half-width, ms | 0.77 ± 0.03 | 0.80 ± 0.03 (8) | - | - |
| AP voltage peak, mV | 32.8 ± 2.1 | 30.7 ± 2.3 (8) | - | - |
| No. of spikes | ||||
| At 100 pA | 0.3 ± 0.2 | 0 ± 0 (11) | 0.4 ± 0.3 | - |
| At 200 pA | 3.3 ± 0.9 | 0.6 ± 0.4† (11) | 1.2 ± 0.4 | - |
| At 300 pA | 7.4 ± 1.0 | 1.8 ± 0.5‡ (11) | 2.2 ± 0.4 | - |
| At 400 pA | 10.9 ± 0.8 | 2.9 ± 0.6‡ (11) | 4.8 ± 0.9 | - |