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Article: Intrinsic neurophysiological properties of hilar ectopic and normotopic dentate granule cells in human temporal lobe epilepsy and a rat model.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Althaus AL; Sagher O; Parent JM; Murphy GG J. Neurophysiol., 2015
Table 2.
Passive membrane properties of all cells recorded from rodents displayed features of DGCs
| Normotopic SE | Ectopic SE | Normotopic Sham | |
|---|---|---|---|
| n | 38 | 7 | 6 |
| Resting membrane potential*, mV | -71.62 ± 0.65 | -65.22 ± 3.15† | -71.57 ± 1.37 |
| Input resistance, MΩ | 282.50 ± 31.65 | 273.45 ± 31.75 | 226.0 ± 32.71 |
| Sag ratio | 1.005 ± 0.001 | 0.999 ± 0.002 | 1.003 ± 0.001 |
| Action potential threshold, mV | -40.79 ± 1.20 | -41.07 ± 2.59 | -37.87 ± 2.29 |
| Action potential spike height, mV | 72.04 ± 2.93 | 63.48 ± 4.84 | 67.49 ± 6.53 |
| Action potential half-width (ms)* | 0.99 ± 0.03 | 1.3 ± 0.14†‡ | 0.95 ± 0.07 |
Values are means ± SE; n, no. of cells. SE, status epilepticus. Ectopic DGCs had depolarized resting membrane potential and wider action potential than normotopic or sham DGCs, respectively. Analyses were done using one-way ANOVA with Tukey's post hoc test for multiple comparisons.
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↵* Main effect determined by one-way ANOVA.
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↵† Significantly different from normotopic SE with post hoc analysis.
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↵‡ Significantly different from sham with post hoc analysis.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Dentate gyrus granule cell | Dentate gyrus normotopic granule cell layer | resting membrane potential (mV) | -71.57 ± 1.37 (6) | -71.57 (mV) | Data Table |
| Dentate gyrus granule cell | Dentate gyrus normotopic granule cell layer | input resistance (MΩ) | 226.0 ± 32.71 (6) | 226.0 (MΩ) | Data Table |
| Dentate gyrus granule cell | Dentate gyrus normotopic granule cell layer | sag ratio | 1.003 ± 0.001 (6) | 1.003 (ratio) | Data Table |
| Dentate gyrus granule cell | Dentate gyrus normotopic granule cell layer | spike threshold (mV) | -37.87 ± 2.29 (6) | -37.87 (mV) | Data Table |
| Dentate gyrus granule cell | Dentate gyrus normotopic granule cell layer | spike amplitude (mV) | 67.49 ± 6.53 (6) | 67.49 (mV) | Data Table |
| Dentate gyrus granule cell | Dentate gyrus normotopic granule cell layer | spike half-width (ms) | 0.95 ± 0.07 (6) | 0.95 (ms) | Data Table |