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Article: Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice.

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Wei W; Li L; Yu G; Ding S; Li C; Zhou FM
J. Neurophysiol., 2013


Table 1.

Intrinsic membrane properties of GP neurons in Pitx3WT and Pitx3Null mice

Mouse TypeCell TypeInput Resistance, MΩMembrane Time Constant, msAP Base Duration, msAP Amplitude, mVAP Threshold, mVfAHP Amplitude, mVIh Sag, mV (trough potential, mV)
Pitx3WTType A373.8 ± 28.7 (166.3-705.8) n = 3737.4 ± 2.3 (14.2-66.9) n = 371.34 ± 0.06 (0.92-1.86) n = 3770.5 ± 1.8 (54.0-91.0) n = 37-41.1 ± 0.7 (-34.2 to -50.0) n = 37-17.4 ± 0.7 (-11.0 to -24.6) n = 378.9 ± 0.7 (n = 25) (at -100.1 + 0.9) (6.1-14.0)
Pitx3WTType B167.2 ± 10.5 (81.9-253.6) n = 2620.2 ± 1.8 (14.6-33.8) n = 260.73 ± 0.01 (0.61-0.89) n = 2671.4 ± 1.8 (53.3-89.5) n = 26-43.3 ± 1.1 (-31.6 to -58.4) n = 26-21.5 ± 0.8 (-16.4 to -30.5) n = 264.8 ± 0.6 (n = 11) (at -97.7 + 0.9) (2.7-7.7)
Pitx3NullType A377.6 ± 24.7 (170.4-720.9) n = 3537.2 ± 2.5 (15.2-73.8) n = 351.38 ± 0.04 (0.95-1.83) n = 3570.8 ± 1.4 (58.6-90.9) n = 35-40.2 ± 0.7 (-35.2 to -51.4) n = 35-17.6 ± 0.6 (-10.8 to -24.5) n = 358.8 ± 0.6 (n = 31) (at -100.1 + 0.9) (6.4-12.5)
Pitx3NullType B171.7 ± 10.4 (96.8-286.5) n = 3021.1 ± 1.3 (12.0-33.3) n = 300.72 ± 0.02 (0.51-0.88) n = 3071.2 ± 1.2 (53.3-90.7) n = 30-43.4 ± 0.8 (-38.1 to -56.1) n = 30-21.1 ± 0.7 (-16.5 to -34.8) n = 304.9 ± 0.5 (n = 14) (at -98.8 + 1.2) (3.0-6.9)
Pitx3WT vs. Pitx3NullType AP > 0.05P > 0.05P > 0.05P > 0.05P > 0.05P > 0.05P > 0.05
Type BP > 0.05P > 0.05P > 0.05P > 0.05P > 0.05P > 0.05P > 0.05
Type A vs. type BWTP < 0.001P < 0.05P < 0.001P > 0.05P > 0.05P < 0.05P < 0.01
HomoP < 0.001P < 0.05P < 0.001P > 0.05P > 0.05P < 0.05P < 0.01

  • Values are means ± SE for n cells. Values in parentheses indicate ranges of individual values. GP, globus pallidus; AP, action potential; fAHP, fast afterhyperpolarization; WT, wild type; Homo, Pitx3Null. P values are from unpaired t-tests.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron input resistance (MΩ) 167.2 ± 10.5 (26) 167.2 (MΩ) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron membrane time constant (ms) 20.2 ± 1.8 (26) 20.2 (ms) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron spike width (ms) 0.73 ± 0.01 (26) 0.73 (ms) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron spike amplitude (mV) 71.4 ± 1.8 (26) 71.4 (mV) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron spike threshold (mV) -43.3 ± 1.1 (26) -43.3 (mV) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron fast AHP amplitude (mV) -21.5 ± 0.8 (26) 21.5 (mV) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron sag amplitude 4.8 ± 0.6 (26) 4.8 (mV) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron input resistance (MΩ) 373.8 ± 28.7 (37) 373.8 (MΩ) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron membrane time constant (ms) 37.4 ± 2.3 (37) 37.4 (ms) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron spike width (ms) 1.34 ± 0.06 (37) 1.34 (ms) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron spike amplitude (mV) 70.5 ± 1.8 (37) 70.5 (mV) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron spike threshold (mV) -41.1 ± 0.7 (37) -41.1 (mV) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron fast AHP amplitude (mV) -17.4 ± 0.7 (37) 17.4 (mV) Data Table
Globus pallidus intrinsic cell dorsal globus pallidus GABAergic neuron sag amplitude 8.9 ± 0.7 (37) 8.9 (mV) Data Table