Article: Neuromodulation by a cytokine: interferon-beta differentially augments neocortical neuronal activity and excitability.

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Hadjilambreva G; Mix E; Rolfs A; Müller J; Strauss U
J. Neurophysiol., 2005

TABLE 1.General sub- and suprathreshold membrane properties of somatosensory pyramidal neurons from the neocortex of Wistar rats



	Layer 2/3	Layer 5

Membrane potential, mV	–75.1 ± 0.9 (45)	–72.6 ± 0.8 (47)
Input resistance, MΩ	34.8 ± 2.5 (45)	33.1 ± 2.5 (47)
Membrane time constant, ms	12.4 ± 0.8 (45)	14.1 ± 1.0 (47)
Action potential amplitude, mV	87.9 ± 1.2 (39)	83.2 ± 3.2 (24)
Action potential width at half height, ms	1.16 ± 0.03 (39)	1.06 ± 0.05 (24)
Action potential rise time (10–90%), ms	0.40 ± 0.01 (39)	0.36 ± 0.01 (24)
Action potential rate of rise, V/s	162.0 ± 7.5 (39)	182.3 ± 13.2 (24)
Rheobase (action potential current threshold), pA	206.8 ± 38.4 (21)	254.0 ± 48.7 (23)
F-I slope, Hz/nA	59.5 ± 6.6 (21)	64.6 ± 9.9 (23)

Data presented as mean ± SE, number of cells in parentheses. Note that the neurons under the pre-treatment with ZD7288 have been excluded from the analysis of the membrane properties. Analysis of single action potential and firing properties were restricted to those neurons which underwent related interferon- ${beta}$ superfusion experiments.

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Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Neocortex pyramidal cell layer 2-3	Layer 2/3 somatosensory cortex pyramidal neurons	input resistance (MΩ)	34.8 ± 2.5 (45)	34.8 (MΩ)	Data Table
Neocortex pyramidal cell layer 5-6	Layer 5 somatosensory pyramidal neurons	input resistance (MΩ)	33.1 ± 2.5 (47)	33.1 (MΩ)	Data Table
Neocortex pyramidal cell layer 2-3	Layer 2/3 somatosensory cortex pyramidal neurons	membrane time constant (ms)	12.4 ± 0.8 (45)	12.4 (ms)	Data Table
Neocortex pyramidal cell layer 5-6	Layer 5 somatosensory pyramidal neurons	membrane time constant (ms)	14.1 ± 1.0 (47)	14.1 (ms)	Data Table
Neocortex pyramidal cell layer 2-3	Layer 2/3 somatosensory cortex pyramidal neurons	spike amplitude (mV)	87.9 ± 1.2 (39)	87.9 (mV)	Data Table
Neocortex pyramidal cell layer 5-6	Layer 5 somatosensory pyramidal neurons	spike amplitude (mV)	83.2 ± 3.2 (24)	83.2 (mV)	Data Table
Neocortex pyramidal cell layer 2-3	Layer 2/3 somatosensory cortex pyramidal neurons	spike half-width (ms)	1.16 ± 0.03 (39)	1.16 (ms)	Data Table
Neocortex pyramidal cell layer 5-6	Layer 5 somatosensory pyramidal neurons	spike half-width (ms)	1.06 ± 0.05 (24)	1.06 (ms)	Data Table
Neocortex pyramidal cell layer 2-3	Layer 2/3 somatosensory cortex pyramidal neurons	spike rise time	0.4 ± 0.01 (39)	0.4 (ms)	Data Table
Neocortex pyramidal cell layer 5-6	Layer 5 somatosensory pyramidal neurons	spike rise time	0.36 ± 0.01 (24)	0.36 (ms)	Data Table
Neocortex pyramidal cell layer 2-3	Layer 2/3 somatosensory cortex pyramidal neurons	spike max rise slope (V/s)	162.0 ± 7.5 (39)	162.0 (mV/ms)	Data Table
Neocortex pyramidal cell layer 5-6	Layer 5 somatosensory pyramidal neurons	spike max rise slope (V/s)	182.3 ± 13.2 (24)	182.3 (mV/ms)	Data Table
Neocortex pyramidal cell layer 2-3	Layer 2/3 somatosensory cortex pyramidal neurons	rheobase	206.8 ± 38.4 (21)	206.8 (pA)	Data Table
Neocortex pyramidal cell layer 5-6	Layer 5 somatosensory pyramidal neurons	rheobase	254.0 ± 48.7 (23)	254.0 (pA)	Data Table
Neocortex pyramidal cell layer 2-3	Layer 2/3 somatosensory cortex pyramidal neurons	FI slope (Hz/nA)	59.5 ± 6.6 (21)	59.5 (Hz/nA)	Data Table
Neocortex pyramidal cell layer 5-6	Layer 5 somatosensory pyramidal neurons	FI slope (Hz/nA)	64.6 ± 9.9 (23)	64.6 (Hz/nA)	Data Table
Neocortex pyramidal cell layer 2-3	Layer 2/3 somatosensory cortex pyramidal neurons	resting membrane potential (mV)	-75.1 ± 0.9 (45)	-75.1 (mV)	Data Table
Neocortex pyramidal cell layer 5-6	Layer 5 somatosensory pyramidal neurons	resting membrane potential (mV)	-72.6 ± 0.8 (47)	-72.6 (mV)	Data Table