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Article: P2Y1 receptor modulation of Ca2+-activated K+ currents in medium-sized neurons from neonatal rat striatal slices.

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Coppi E; Pedata F; Gibb AJ
J. Neurophysiol., 2012


Table 2.

Current-clamp parameters in the absence and in the presence of 2-MeSADP

Control 2-MeSADP
First AP amplitude (mV) 107 ± 2.42 108 ± 2.30
AP threshold −33.5 ± 0.70 −34.8 ± 0.78
AP depolarization rate (mV/ms) 133 ± 3.53 129 ± 4.16
AP hyperpolarization rate (mV/ms) −92.1 ± 3.69 −85.5 ± 3.98
AP width (ms) 3.16 ± 0.12 3.29 ± 0.12
AP latency (ms) 79.4 ± 11.7 124 ± 26.4
mAHP amplitude (mV) 9.32 ± 0.58 10.21 ± 0.74
ISI first-second (ms) 75.9 ± 8.86 116 ± 13.8*
ISI second-third (ms) 74.2 ± 14.4 124 ± 19.3*
Spike-frequency adaptation 1.15 ± 0.07 1.05 ± 0.08
AP frequency (Hz) 15.4 ± 1.25 9.69 ± 1.01*

  • The values of different current-clamp parameters, recorded in 26 medium-spiny neurons, are expressed as mean ± SE and show the average of values obtained by suprathreshold current injection for steps to an average voltage of −40.7 mV.

  • ↵* P < 0.05 from control values, Student's paired t-test. AP, action potential; mAHP, medium afterhyperpolarization potential; ISI, interspike interval.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum medium spiny neuron spike amplitude from resting (mV) 107.0 ± 2.42 (7) 107.0 (mV) Data Table
Neostriatum medium spiny neuron spike threshold -33.5 ± 0.7 (7) -33.5 (mV) Data Table
Neostriatum medium spiny neuron spike max rise slope (mV/ms) 133.0 ± 3.53 (7) 133.0 (mV/ms) Data Table
Neostriatum medium spiny neuron spike max decay slope (mV/ms) -92.1 ± 3.69 (7) 92.1 (mV/ms) Data Table
Neostriatum medium spiny neuron spike width (ms) 3.16 ± 0.12 (7) 3.16 (ms) Data Table
Neostriatum medium spiny neuron first spike latency (ms) 79.4 ± 11.7 (7) 79.4 (ms) Data Table
Neostriatum medium spiny neuron AHP amplitude (mV) 9.32 ± 0.58 (7) 9.32 (mV) Data Table
Neostriatum medium spiny neuron adaptation ratio (last/first ISI) 1.15 ± 0.07 (7) 1.15 (ratio) Data Table
Neostriatum medium spiny neuron firing frequency (Hz) 15.4 ± 1.25 (7) 15.4 (Hz) Data Table