Table 1. Intrinsic membrane properties of different groups of recorded neurons
| PYR1 (n = 9) | PYR2 (n = 10) | FS (n = 8) | |
|---|---|---|---|
| Values ± x are means ± s.e.m. Ih, membrane potential sag, reflective of hyperpolarization-activated cation current; AHP, afterhyperpolarization potential; RS, regular spiking; IB, intrinsically bursting; f–I, frequency–current. Firing properties were calculated for the first depolarizing step (in 50 pA increments) that reliably produced action potentials (100 pA for PYR, 250 pA for FS).The f–I slope and adaptation index were calculated as described in the Methods. †P < 0.05 statistically different from PYR1. *P < 0.05 statistically different from PYR2. | |||
| DHO – membrane depolarization (mV) | 10.0 ± 0.4* | 2.7 ± 0.3 | 5.2 ± 0.8†* |
| Resting membrane potential (mV) | −64.1 ± 0.9 | −62.0 ± 1.3 | −67.4 ± 1.5* |
| Input resistance (MΩ) | |||
| Control | 119.7 ± 19.5 | 116.6 ± 15.8 | 80.9 ± 8.5†* |
| DHO | 127.6 ± 20.5 | 129.8 ± 16.4 | 79.3 ± 8.4†* |
| Capacitance (pF) | 125.5 ± 22.3 | 116.9 ± 13.5 | 38.2 ± 5.3†* |
| Ih (mV) | 4.30 ± 0.8 | 4.35 ± 0.8 | 1.17 ± 0.3†* |
| Post-train AHP (mV) | 4.32 ± 0.8 | 3.72 ± 0.7 | 0.95 ± 0.1†* |
| Firing properties | |||
| Type (RS/IB) | 8/1 | 8/2 | |
| Mean firing frequency (Hz) | 14.8 ± 2.6 | 14.1 ± 3.0 | 73.4 ± 35.3†* |
| f–I slope | 7.4 ± 0.2 | 7.0 ± 0.4 | 120.8 ± 14.3†* |
| Adaptation index | 18.5 ± 3.1 | 20.3 ± 4.8 | 9.1 ± 5.9 |
| Mean age (postnatal days) | 19.8 ± 3.0 | 17.8 ± 1.0 | 21.0 ± 0.9 |
| (range) | (17–27) | (16–27) | (18–27) |