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Article: Selective silencing of Na(V)1.7 decreases excitability and conduction in vagal sensory neurons.

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Muroi Y; Ru F; Kollarik M; Canning BJ; Hughes SA; Walsh S; Sigg M; Carr MJ; Undem BJ
J. Physiol. (Lond.), 2011


Table 3. Resting membrane potential, action potential threshold, rheobase and spike width at 0 mV of (n) number of experiments (Mean ± SEM)

Naïve Control NaV1.7 shRNA
Statistical comparisons were made using one-way ANOVAs followed by Tukey's post hoc test. An asterisk denotes a significant difference between naïve and control neurons (*P < 0.01 compared to naïve and control groups).
Resting membrane potential (mV) −50.7 ± 3.07 (7) −50.4 ± 1.45 (12) −48.3 ± 3.61 (8)
Threshold (mV) −41.6 ± 1.13 (12) −46.1 ± 0.70 (12) −29.3 ± 2.42 (9)*
Rheobase (pA) 24.2 ± 2.88 (12) 17.8 ± 3.64 (12) 105 ± 13.23 (9)*
Width at 0 mV (ms) 3.7 ± 0.61 (12) 2.3 ± 0.29 (12) 2.8 ± 0.22 (9)

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell resting membrane potential (mV) -50.7 ± 3.07 (7) -50.7 (mV) Data Table
Dorsal root ganglion cell spike threshold (mV) -41.6 ± 1.13 (12) -41.6 (mV) Data Table
Dorsal root ganglion cell rheobase (pA) 24.2 ± 2.88 (12) 24.2 (pA) Data Table