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Article: Selective optogenetic stimulation of cholinergic axons in neocortex.

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Kalmbach A; Hedrick T; Waters J
J. Neurophysiol., 2012


Table 1.

Cellular properties of infected cholinergic neurons

400-nl Injections 800-nl Injections
Resting membrane potential, mV −48 ± 1.8 (n = 9; P > 0.1) −43 ± 1.8* (n = 13; P < 0.01)
Resting input resistance, MΩ 268 ± 42 (n = 9; P > 0.1) 152 ± 27* (n = 13; P < 0.05)
Rectification (CAR), MΩ/nA 400 ± 137 (n = 9; P > 0.1) 124 ± 61* (n = 13; P < 0.05)
Resting membrane time constant, ms 28.2 ± 3.5 (n = 9; P > 0.1) 15.3 ± 3.1 (n = 13; P > 0.05)
Sag ratio 0.97 ± 0.01 (n = 9; P > 0.1)
Rheobase, pA 33 ± 4.6 (n = 9; P > 0.1) 32 ± 3.2 (n = 13; P > 0.1)
Action potential threshold, mV −31.9 ± 0.8 (n = 9; P > 0.1) −26.8 ± 2.2 (n = 13; P > 0.1)
Action potential amplitude, mV 66.7 ± 4.5 (n = 9; P > 0.1) 55.6 ± 5.0 (n = 13; P > 0.1)
Action potential half-width, ms 0.52 ± 0.03 (n = 9; P > 0.1) 0.69 ± 0.02* (n = 13; P < 0.01)
Action potential 10-90% rise time, ms 0.25 ± 0.02 (n = 9; P > 0.1) 0.31 ± 0.02* (n = 13; P < 0.05)
Action potential 10-90% decay time, ms 0.57 ± 0.05 (n = 9; P > 0.1) 0.67 ± 0.04* (n = 13; P < 0.01)
fAHP amplitude, mV 16 ± 2.6 (n = 9; P > 0.1) 12 ± 1.8 (n = 13; P > 0.1)
sAHP amplitude, mV 8.7 ± 2.1 (n = 8; P > 0.1) 5.5 ± 1.5* (n = 9; P < 0.01)
sAHP latency, ms 34 ± 3.0 (n = 8; P > 0.1) 54 ± 12 (n = 9; P > 0.1)

  • Values are means ± SE. n Indicates number of neurons.

  • ↵* Significant difference from that of cholinergic neurons in nucleus basalis in uninfected mice [unpaired t-test; comparison with results in Table 1 of Hedrick and Waters (2010)]. fAHP, fast afterhyperpolarization; sAHP, slow afterhyperpolarization.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Basalis nucleus cholinergic neuron membrane time constant (ms) 28.2 ± 3.5 28.2 (ms) Data Table
Basalis nucleus cholinergic neuron sag ratio 0.97 ± 0.01 0.97 (ratio) Data Table
Basalis nucleus cholinergic neuron rheobase (pA) 33.0 ± 4.6 33.0 (pA) Data Table
Basalis nucleus cholinergic neuron resting membrane potential (mV) -48.0 ± 1.8 -48.0 (mV) Data Table
Basalis nucleus cholinergic neuron spike threshold (mV) -31.9 ± 0.8 -31.9 (mV) Data Table
Basalis nucleus cholinergic neuron spike amplitude (mV) 66.7 ± 4.5 66.7 (mV) Data Table
Basalis nucleus cholinergic neuron spike half-width (ms) 0.52 ± 0.03 0.52 (ms) Data Table
Basalis nucleus cholinergic neuron spike rise time (ms) 0.25 ± 0.02 0.25 (ms) Data Table
Basalis nucleus cholinergic neuron spike decay time (ms) 0.57 ± 0.05 0.57 (ms) Data Table
Basalis nucleus cholinergic neuron fast AHP amplitude (mV) 16.0 ± 2.6 16.0 (mV) Data Table
Basalis nucleus cholinergic neuron slow AHP amplitude (mV) 8.7 ± 2.1 8.7 (mV) Data Table
Basalis nucleus cholinergic neuron slow AHP duration (ms) 34.0 ± 3.0 34.0 (ms) Data Table
Basalis nucleus cholinergic neuron input resistance (MΩ) 268.0 ± 42.0 268.0 (MΩ) Data Table